Periosteal distraction osteogenesis versus immediate periosteal elevation in a rat model: Histological and micro-CT analysis.

Nakahara, Ken; Haga-Tsujimura, Maiko; Sawada, Kosaku; Mottini, Matthias; Schaller, Benoît; Saulacic, Nikola (2017). Periosteal distraction osteogenesis versus immediate periosteal elevation in a rat model: Histological and micro-CT analysis. Journal of cranio-maxillo-facial surgery, 45(5), pp. 620-627. Elsevier 10.1016/j.jcms.2017.01.030

[img] Text
1-s2.0-S1010518217300410-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (5MB) | Request a copy

PURPOSE The aim of the present study was to compare periosteal distraction osteogenesis (PDO) to immediate periosteal elevation (IPE) in terms of de novo bone formation. MATERIAL AND METHODS Animals of PDO Group were subjected to a 7-day latency period and a 10-day distraction period. Distraction device in IPE Group were activated for 1 mm at placement. Both groups of animals were euthanized at 17, 31 and 45-day following surgery and the samples analyzed histologically and by micro-CT. Total gap region (TG) was divided in two subregions, less than 0.5 mm (LG) and over 0.5 mm of the gap height (HG). RESULTS Bone formation in PDO Group was observed in the distal region of the distraction gap, whereas in IPE Group proximally and distally from the distraction gap. Bone volume increased in both groups in LG, HG and TG (p < 0.001), while bone mineral density only in HG (p = 0.001). More new bone was observed in PDO than in IPE Group in HG (p = 0.017) and in TG (p < 0.001), without differences found in bone mineral density. CONCLUSIONS The function of immediately elevated periosteum is limited to the distance to the underlying bone. PDO may be successfully applied to maintain the osteogenic capacity of elevated periosteum.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie

UniBE Contributor:

Nakahara, Ken; Haga-Tsujimura, Maiko; Sawada, Kosaku; Mottini, Matthias; Schaller, Benoît and Saulacic, Nikola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1010-5182

Publisher:

Elsevier

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

08 Mar 2018 09:26

Last Modified:

08 Mar 2018 09:29

Publisher DOI:

10.1016/j.jcms.2017.01.030

PubMed ID:

28285922

Uncontrolled Keywords:

Animal model Bone Distraction osteogenesis Periosteum

BORIS DOI:

10.7892/boris.110974

URI:

https://boris.unibe.ch/id/eprint/110974

Actions (login required)

Edit item Edit item
Provide Feedback