Comparison of acid-base and electrolyte changes following administration of 6% hydroxyethyl starch 130/0.42 in a saline and a polyionic solution in anaesthetized dogs

Adamik, Katja N.; Obrador, Rafael; Howard, Judith (2018). Comparison of acid-base and electrolyte changes following administration of 6% hydroxyethyl starch 130/0.42 in a saline and a polyionic solution in anaesthetized dogs. Veterinary anaesthesia and analgesia, 45(3), pp. 260-268. Elsevier 10.1016/j.vaa.2017.11.003

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Objective To evaluate the effects of a 6% hydroxyethyl starch (130/0.42) in either a buffered, electrolyte-balanced (HES-BAL) or saline (HES-SAL) carrier solution on electrolyte concentrations and acid-base parameters in healthy anaesthetized dogs.
Study design Prospective randomised clinical study.
Animals Forty client-owned dogs undergoing general anaesthesia for elective surgical procedures or diagnostic imaging.
Methods During anaesthesia, dogs were administered 15 mL kg−1 IV of either HES-SAL (n = 20) or HES-BAL (n = 20) over 30–40 minutes. Jugular blood samples were analysed before (T0) and 5 minutes (T5), 1 hour (T60) and 3 hours (T180) after fluid administration. . Sodium, potassium, chloride, ionised calcium, phosphate, albumin, pH, venousPCO2, base excess, bicarbonate and anion gap were determined and strong ion difference and total quantity of weak nonvolatile acids were calculated for each time point.
Results Chloride was significantly increased at T5, T60, and T180 compared with T0 after HES-SAL, and was significantly greater after HES-SAL than after HES-BAL at T5 (p = 0.042). Ionised calcium was significantly decreased at T5 compared with T0 after HES-SAL, and was significantly lower after HES-SAL than after HES-BAL at T5 (p < 0.001). Bicarbonate was significantly lower after HES-SAL than after HES-BAL at T5 (p = 0.004) and T60 (p = 0.032). Base excess was significantly lower after HES-SAL than after HES-BAL at T5 (p < 0.001) and T60 (p = 0.007). Strong ion difference was significantly decreased after HES-SAL at T5 and T60 compared with T0, and was significantly lower after HES-SAL than after HES-BAL at T5 (p = 0.027). Mean electrolyte and acid-base parameters remained within or marginally outside of reference intervals.
Conclusion and clinical relevance Changes in both groups were minor and short-lived with either fluid in healthy individuals, but might become clinically relevant with higher fluid doses or in critically-ill dogs.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Central Clinical Laboratory 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Intensive Care Unit, Small Animal Clinic
UniBE Contributor:	Adamik, Katja-Nicole, Obrador de Aguilar, Rafael, Howard, Judith
Subjects:	600 Technology > 630 Agriculture
ISSN:	1467-2987
Publisher:	Elsevier
Language:	English
Submitter:	Katja-Nicole Adamik
Date Deposited:	10 May 2019 14:55
Last Modified:	02 Mar 2023 23:30
Publisher DOI:	10.1016/j.vaa.2017.11.003
PubMed ID:	29506859
URI:	https://boris.unibe.ch/id/eprint/110985