The Efficacy of Fibrin Sealant Patches in Reducing the Incidence of Lymphatic Morbidity After Radical Lymphadenectomy: A Meta-Analysis.

Gasparri, Maria Luisa; Ruscito, Ilary; Bolla, Daniele; Benedetti Panici, Pierluigi; Mueller, Michael; Papadia, Andrea (2017). The Efficacy of Fibrin Sealant Patches in Reducing the Incidence of Lymphatic Morbidity After Radical Lymphadenectomy: A Meta-Analysis. International journal of gynecological cancer, 27(6), pp. 1283-1292. Lippincott Williams & Wilkins 10.1097/IGC.0000000000001051

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BACKGROUND Although pivotal in the oncological management of most tumors, radical lymphadenectomy is associated with a significant number of lymphatic complications. The aim of this meta-analysis is to evaluate the efficacy of fibrinogen sealant patches in reducing lymphadenectomy-related postoperative complications. METHODS/MATERIALS The electronic databases PubMed, Medline, and Scopus were searched using the terms "lymphadenectomy" or "lymph node dissection" and "TachoSil," "TachoComb," or "fibrin sealant patch." Series evaluating the efficacy of fibrin-thrombin collagen sealant patches were included in the meta-analysis. RESULTS Overall, 26 studies were retrieved through the literature search. Ten studies including 720 patients met selection criteria. The use of fibrin-thrombin sealant patches to the sole scope of reducing lymphadenectomy-related complications significantly reduced the incidence of lymphocele, symptomatic lymphocele, the need of percutaneous drainage procedures, the volume of lymph drained, and the duration of the drainage. No effect on wound and/or lymphocele infection was noted. CONCLUSIONS This meta-analysis demonstrates that the use of fibrin-thrombin sealant patches significantly reduces the total volume of lymph drained, the duration of the drainage, the incidence of lymphocele and symptomatic lymphocele, and the need for postoperative percutaneous drainage procedures. Its use does not affect the incidence of wound or lymphocele infections.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Mueller, Michael and Papadia, Andrea

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1048-891X

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Monika Zehr

Date Deposited:

26 Feb 2018 14:34

Last Modified:

04 Dec 2019 02:53

Publisher DOI:

10.1097/IGC.0000000000001051

PubMed ID:

28640177

BORIS DOI:

10.7892/boris.111025

URI:

https://boris.unibe.ch/id/eprint/111025

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