Resistance to polymyxins: genetic bases, epidemiology, and detection issues

Endimiani, Andrea (20 September 2017). Resistance to polymyxins: genetic bases, epidemiology, and detection issues. In: XXII Congreso Latinoamericano de Bioquímica Clínica. Punta del Este, Uruguay. 20.09.2017.

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Polymyxins are old designed antibiotics that have recently regained significant interest as a consequence of the increasing prevalence of infections due to multidrug-resistant Gram-negative bacteria. In particular, colistin and polymyxin B are reconsidered as last-resort antibiotics in clinical medicine to treat infections due to extensively- or pan-drug-resistant Gram-negative bacteria producing carbapenemases. Unfortunately, polymyxin-resistant bacteria are also emerging in human, veterinary, food chain and environmental settings. This talk presents recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyxin resistance determinant MCR-1, MCR-2 and MCR-3. Epidemiological features summarizing the current knowledge in the different settings and both genotypic and currently available phenotypic methods that provide relevant information for diagnostic laboratories will be also discussed.

Item Type:

Conference or Workshop Item (Speech)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Endimiani, Andrea

Subjects:

500 Science > 570 Life sciences; biology

Funders:

[42] Schweizerischer Nationalfonds

Projects:

[577] SNF project 153377 to Andrea Endimiani

Language:

Español

Submitter:

Andrea Endimiani

Date Deposited:

22 Feb 2018 15:37

Last Modified:

23 Oct 2019 06:40

BORIS DOI:

10.7892/boris.111028

URI:

https://boris.unibe.ch/id/eprint/111028

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