Beyond circulating microRNA biomarkers: Urinary microRNAs in ovarian and breast cancer.

Gasparri, Maria Luisa; Casorelli, Assunta; Bardhi, Erlisa; Besharat, Aris Raad; Savone, Delia; Ruscito, Ilary; Farooqi, Ammad Ahmad; Papadia, Andrea; Mueller, Michael; Ferretti, Elisabetta; Benedetti Panici, Pierluigi (2017). Beyond circulating microRNA biomarkers: Urinary microRNAs in ovarian and breast cancer. Tumor biology, 39(5), p. 1010428317695525. Springer 10.1177/1010428317695525

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Breast cancer is the most common malignancy in women worldwide, and ovarian cancer is the most lethal gynecological malignancy. Women carrying a BRCA1/2 mutation have a very high lifetime risk of developing breast and ovarian cancer. The only effective risk-reducing strategy in BRCA-mutated women is a prophylactic surgery with bilateral mastectomy and bilateral salpingo-oophorectomy. However, many women are reluctant to undergo these prophylactic surgeries due to a consequent mutilated body perception, unfulfilled family planning, and precocious menopause. In these patients, an effective screening strategy is available only for breast cancer, but it only consists in close radiological exams with a significant burden for the health system and a significant distress to the patients. No biomarkers have been shown to effectively detect breast and ovarian cancer at an early stage. MicroRNAs (miRNAs) are key regulatory molecules operating in a post-transcriptional regulation of gene expression. Aberrant expression of miRNAs has been documented in several pathological conditions, including solid tumors, suggesting their involvement in tumorigenesis. miRNAs can be detected in blood and urine and could be used as biomarkers in solid tumors. Encouraging results are emerging in gynecological malignancy as well, and suggest a different pattern of expression of miRNAs in biological fluids of breast and ovarian cancer patients as compared to healthy control. Aim of this study is to highlight the role of the urinary miRNAs which are specifically associated with cancer and to investigate their role in early diagnosis and in determining the prognosis in breast and ovarian cancer.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Papadia, Andrea and Mueller, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1010-4283

Publisher:

Springer

Language:

English

Submitter:

Monika Zehr

Date Deposited:

22 Mar 2018 10:37

Last Modified:

23 Oct 2019 19:47

Publisher DOI:

10.1177/1010428317695525

PubMed ID:

28459207

Uncontrolled Keywords:

BRCA biomarkers breast cancer circulating microRNA ovarian cancer urinary microRNA

BORIS DOI:

10.7892/boris.111038

URI:

https://boris.unibe.ch/id/eprint/111038

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