Orsiro cobalt-chromium sirolimus-eluting stent: present and future perspectives.

Iglesias, Juan F; Roffi, Marco; Degrauwe, Sophie; Secco, Gioel Gabrio; Aminian, Adel; Windecker, Stephan; Pilgrim, Thomas (2017). Orsiro cobalt-chromium sirolimus-eluting stent: present and future perspectives. Expert review of medical devices, 14(10), pp. 773-788. Taylor & Francis 10.1080/17434440.2017.1378091

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INTRODUCTION New-generation drug-eluting stents (DES) represent the current standard of care in patients undergoing percutaneous coronary intervention (PCI). Biodegradable polymer DES (BP-DES) were recently developed to overcome current limitations of newer-generation durable polymer DES (DP-DES) attributed to sustained inflammatory responses induced by permanent polymers. The Orsiro DES (Biotronik AG, Bülach, Switzerland) is a novel thin-strut cobalt-chromium sirolimus-eluting stent with biodegradable polymer that features some of the latest developments in DES technology. Areas covered: This article aims to review the currently available evidence on the clinical performance of the Orsiro BP-DES and its future perspectives. Expert commentary: The Orsiro DES is a recent newer-generation BP-DES that combines a highly deliverable thin-strut cobalt-chromium stent platform and a unique hybrid concept with passive and active coatings designed to enhance tissue biocompatibility. In preclinical and intravascular imaging studies, the Orsiro BP-DES was shown to induce low inflammation and promote very early arterial healing. Recently, large randomized non-inferiority clinical trials have shown similar short- and mid-term efficacy and safety outcomes with Orsiro BP-DES compared with currently established newer-generation DES among all-comers and high-risk subgroups. The potential clinical superiority of Orsiro BP-DES over Xience DP-DES in patients with STEMI is currently investigated in the BIOSTEMI trial (NCT02579031).

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan and Pilgrim, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1745-2422

Publisher:

Taylor & Francis

Language:

English

Submitter:

Nadia Biscozzo

Date Deposited:

26 Feb 2018 15:49

Last Modified:

26 Feb 2018 15:49

Publisher DOI:

10.1080/17434440.2017.1378091

PubMed ID:

28889769

Uncontrolled Keywords:

Biodegradable polymer Orsiro drug-eluting stent ST-elevation myocardial infarction percutaneous coronary intervention thin-struts stent

URI:

https://boris.unibe.ch/id/eprint/111066

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