Serum and follicular fluid testosterone concentrations do not correlate, questioning the impact of androgen supplementation on the follicular endocrine milieu.

von Wolff, Michael; Stute, Petra; Eisenhut, Markus; Marti, Ulrich; Bitterlich, Norman; Bersinger, Nick A. (2017). Serum and follicular fluid testosterone concentrations do not correlate, questioning the impact of androgen supplementation on the follicular endocrine milieu. Reproductive biomedicine online, 35(5), pp. 616-623. Elsevier 10.1016/j.rbmo.2017.07.012

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Basic research into a possible link between serum and follicular fluid androgen concentrations to detemine whether androgen supplementation in low responders affects follicular endocrine milieu is still lacking. Ninety-seven women (aged 28-43 years) undergoing one natural IVF cycle without any hormone stimulation were analysed. Serum and follicular fluid were collected at the time of follicle aspiration, and the concentrations of LH, total testosterone, oestradiol, dehydroepiandrosterone and anti-Mullerian hormone (AMH) were determined. Serum LH (P = 0.003) and AMH (P = 0.026) concentrations, and follicular fluid AMH (P = 0.015) decreased with increasing age. Within follicular fluid, total testosterone was correlated with oestradiol (P < 0.001) and AMH (P = 0.010); LH correlated with AMH (P = 0.005). Correlation analysis of serum and follicular fluid hormone concentrations revealed that LH, oestradiol and AMH correlated (P < 0.001), whereas testosterone did not. Testosterone serum concentrations did not correlate with other follicular fluid hormones, such as dehydroepiandrosterone, oestradiol and AMH, whereas serum LH correlated with follicular flulid AMH (P < 0.008). Follicular fluid hormone concentrations seem to be independent from serum testosterone. Therefore, it is questionable whether an increase in serum testosterone concentration by androgen supplementation could improve the follicular endocrine milieu.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Endometrium & Ovar
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Endokrinologie der Brust

UniBE Contributor:

von Wolff, Michael; Stute, Petra; Eisenhut, Markus and Bersinger, Nick A.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1472-6483

Publisher:

Elsevier

Language:

English

Submitter:

Monika Zehr

Date Deposited:

29 Mar 2018 11:20

Last Modified:

29 Mar 2018 11:20

Publisher DOI:

10.1016/j.rbmo.2017.07.012

PubMed ID:

28821386

Uncontrolled Keywords:

Anti-Müllerian hormone Follicular fluid LH Natural cycle IVF Testosterone

BORIS DOI:

10.7892/boris.111084

URI:

https://boris.unibe.ch/id/eprint/111084

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