Neuroinflammation in Ischemic Pediatric Stroke.

Steinlin, Maja (2017). Neuroinflammation in Ischemic Pediatric Stroke. Seminars in pediatric neurology, 24(3), pp. 201-206. Elsevier 10.1016/j.spen.2017.08.006

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Over the last decades, the importance of inflammatory processes in pediatric stroke have become increasingly evident. Ischemia launches a cascade of events: activation and inhibition of inflammation by a large network of cytokines, adhesion and small molecules, protease, and chemokines. There are major differences in the neonatal brain compared to adult brain, but developmental trajectories of the process during childhood are not yet well known. In neonatal stroke ischemia is the leading pathophysiology, but infectious and inflammatory processes have a significant input into the course and degree of tissue damage. In childhood, beside inflammation lanced by ischemia itself, the event of ischemia might be provoked by an underlying inflammatory pathophysiology: transient focal arteriopathy, dissection, sickle cell anemia, Moyamoya and more generalized in meningitides, generalized vasculitis or genetic arteriopathies (as in ADA2). Focal inflammatory reactions tend to be located in the distal part of the carotid artery or the proximal medial arteries, but generalized processes rather tend to affect the small arteries.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Steinlin, Maja

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1558-0776

Publisher:

Elsevier

Language:

English

Submitter:

Sinthuja Rajkumar

Date Deposited:

26 Mar 2018 10:01

Last Modified:

23 Oct 2019 03:44

Publisher DOI:

10.1016/j.spen.2017.08.006

PubMed ID:

29103427

BORIS DOI:

10.7892/boris.111156

URI:

https://boris.unibe.ch/id/eprint/111156

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