Intramuscular Testosterone Supplementation Ameliorates Depression in Hypogonadal Men: A Retrospective Study in an Outpatient Department.

Miclea, A; Miclea, M; Pistor, M; Stegmayer, K.; Hoepner, Robert (2018). Intramuscular Testosterone Supplementation Ameliorates Depression in Hypogonadal Men: A Retrospective Study in an Outpatient Department. Pharmacopsychiatry, 51(6), pp. 257-262. Thieme 10.1055/s-0043-125214

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INTRODUCTION

Substantial evidence has indicated an association between hypogonadism and depressive symptoms, which led to the conduction of studies that found an ameliorating effect of testosterone (T) supplementation (S) upon depression in men.

METHODS

Retrospective analysis of medical records identified 16 depressed, hypogonadal men who have not responded adequately to initial antidepressant therapy and subsequently received intramuscular T injections. Following the proposal of Button et al., a minimal clinically important difference was defined as an 18% reduction of the Beck Depression Inventory-II (BDI-II) score.

RESULTS

After TS, the BDI-II score decreased by approximately 31% (p<0.01), from 27.2 (mean; standard deviation [SD] 11.8) to 18.8 (mean; SD 11.3). Patients with baseline BDI-II scores ranging from 29 to 63 (severe depression) showed a significantly higher absolute and relative reduction through TS. Also, men with a shorter depression duration (<2 years) demonstrated a greater benefit.

CONCLUSIONS

The depressed, hypogonadal men generally benefited from TS given that the BDI-II score reduction was almost twice as much as needed for a minimal clinically important difference.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Stegmayer, Katharina Deborah Lena and Hoepner, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0176-3679

Publisher:

Thieme

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

16 Apr 2018 11:59

Last Modified:

15 Oct 2020 08:48

Publisher DOI:

10.1055/s-0043-125214

PubMed ID:

29390199

BORIS DOI:

10.7892/boris.111172

URI:

https://boris.unibe.ch/id/eprint/111172

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