Miclea, A; Miclea, M; Pistor, M; Stegmayer, K.; Hoepner, Robert (2018). Intramuscular Testosterone Supplementation Ameliorates Depression in Hypogonadal Men: A Retrospective Study in an Outpatient Department. Pharmacopsychiatry, 51(6), pp. 257-262. Thieme 10.1055/s-0043-125214
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
s-0043-125214.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (272kB) | Request a copy |
INTRODUCTION
Substantial evidence has indicated an association between hypogonadism and depressive symptoms, which led to the conduction of studies that found an ameliorating effect of testosterone (T) supplementation (S) upon depression in men.
METHODS
Retrospective analysis of medical records identified 16 depressed, hypogonadal men who have not responded adequately to initial antidepressant therapy and subsequently received intramuscular T injections. Following the proposal of Button et al., a minimal clinically important difference was defined as an 18% reduction of the Beck Depression Inventory-II (BDI-II) score.
RESULTS
After TS, the BDI-II score decreased by approximately 31% (p<0.01), from 27.2 (mean; standard deviation [SD] 11.8) to 18.8 (mean; SD 11.3). Patients with baseline BDI-II scores ranging from 29 to 63 (severe depression) showed a significantly higher absolute and relative reduction through TS. Also, men with a shorter depression duration (<2 years) demonstrated a greater benefit.
CONCLUSIONS
The depressed, hypogonadal men generally benefited from TS given that the BDI-II score reduction was almost twice as much as needed for a minimal clinically important difference.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Stegmayer, Katharina Deborah Lena, Hoepner, Robert |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0176-3679 |
Publisher: |
Thieme |
Language: |
English |
Submitter: |
Stefanie Hetzenecker |
Date Deposited: |
16 Apr 2018 11:59 |
Last Modified: |
05 Dec 2022 15:10 |
Publisher DOI: |
10.1055/s-0043-125214 |
PubMed ID: |
29390199 |
BORIS DOI: |
10.7892/boris.111172 |
URI: |
https://boris.unibe.ch/id/eprint/111172 |
Actions (login required)
 |
Edit item |