Depression in blepharospasm: a question of facial feedback?

Bedarf, Janis Rebecca; Kebir, Sied; Michelis, Joan Philipp; Wabbels, Bettina; Paus, Sebastian (2017). Depression in blepharospasm: a question of facial feedback? Neuropsychiatric disease and treatment, 13, pp. 1861-1865. Dove Medical Press 10.2147/NDT.S141066

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Depression is the most important nonmotor symptom in blepharospasm (BL). As facial expression influences emotional perception, summarized as the facial feedback hypothesis, we investigated if patients report fewer depressive symptoms if injections of botulinum neurotoxin (BoNT) include the "grief muscles" of the glabellar region, compared to treatment of orbicularis oculi muscles alone. Ninety BL patients were included, half of whom had BoNT treatment including the frown lines. While treatment pattern did not predict depressive symptoms overall, subgroup analysis revealed that in male BL patients, BoNT injections into the frown lines were associated with remarkably less depressive symptoms. We hypothesize that in BL patients presenting with dystonia of the eyebrow region, BoNT therapy should include frown line application whenever justified, to optimize nonmotor effects of BoNT denervation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Michelis, Joan Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1176-6328

Publisher:

Dove Medical Press

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

12 Mar 2018 08:57

Last Modified:

28 Oct 2019 20:32

Publisher DOI:

10.2147/NDT.S141066

PubMed ID:

28761348

Uncontrolled Keywords:

blepharospasm botulinum neurotoxin depression facial feedback frown lines grief muscles

BORIS DOI:

10.7892/boris.111173

URI:

https://boris.unibe.ch/id/eprint/111173

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