Treatment-related psychological stress in different in vitro fertilization therapies with and without gonadotropin stimulation.

Haemmerli Keller, Katja; Alder, Gilliane; Loewer, Lennard; Fäh, Monika; Rohner, Susanne; von Wolff, Michael (2018). Treatment-related psychological stress in different in vitro fertilization therapies with and without gonadotropin stimulation. Acta obstetricia et gynecologica Scandinavica, 97(3), pp. 269-276. Wiley-Blackwell 10.1111/aogs.13281

[img] Text
Keller_et_al-2018-Acta_Obstetricia_et_Gynecologica_Scandinavica 29247514.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (224kB) | Request a copy

INTRODUCTION Infertility treatments such as in vitro fertilization (IVF) impose substantial distress. However, the specific role of individual contributory factors remains unclear. We therefore compared treatment-related psychological stress in IVF treatments with (cIVF) and without (NC-IVF) gonadotropin stimulation, as cIVF includes potentially stressful factors such as ovarian stimulation, anesthesia, embryo selection and cryopreservation, whereas NC-IVF does not. MATERIAL AND METHODS Women were offered to have cIVF or NC-IVF. Validated psychological questionnaires filled in online before, during and after completed treatment cycle(s) at home were used to analyze psychological distress and treatment-related satisfaction and quality of life. To avoid different pregnancy rates in the two treatment groups, one cIVF was compared with three NC-IVF therapies, resulting in the same cumulative pregnancy rate. RESULTS Data from 57 NC-IVF and 62 cIVF patients were evaluated. NC-IVF resulted in a similar overall clinical pregnancy rate than one cIVF. NC-IVF patients had a significantly lower level of depression (CES-D, 13.4 vs. 15.7, p < 0.05) and a higher satisfaction with the treatment (Treatment FertiQoL, 67.9 vs. 62.9, p < 0.05) compared with cIVF patients. The level of psychological distress increased during c-IVF treatment and decreased during NC-IVF treatment. In contrast, during NC-IVF treatment there was a significant increase in satisfaction with the treatment, whereas satisfaction with treatment in the cIVF patients decreased. CONCLUSIONS Factors other than just pregnancy rate seem to have an impact on psychological stress in IVF treatment. Due to reduced psychological stress in NC-IVF, this treatment could be especially considered in psychologically stressed women.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Fäh, Monika; Rohner, Susanne and von Wolff, Michael


600 Technology > 610 Medicine & health








Monika Zehr

Date Deposited:

17 Apr 2018 10:00

Last Modified:

17 Apr 2018 10:00

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Fertility Quality of Life Questionnaire Infertility depression natural cycle in vitro fertilization psychological distress




Actions (login required)

Edit item Edit item
Provide Feedback