Follicular flushing in natural cycle IVF does not affect the luteal phase - a prospective controlled study.

von Wolff, Michael; Kohl, Alexandra Sabrina; Stute, Petra; Fäh, Monika; Otti-Rosebrock, Gesa; Schürch, R; Rohner, Susanne (2017). Follicular flushing in natural cycle IVF does not affect the luteal phase - a prospective controlled study. Reproductive biomedicine online, 35(1), pp. 37-41. Elsevier 10.1016/j.rbmo.2017.04.003

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In contrast to multifollicular IVF, follicular flushing seems to increase the efficacy of monofollicular IVF treatments such as natural cycle IVF (NC-IVF). However, because follicular flushing causes loss of granulosa cells, it might negatively affect luteal phase length and endocrine function of the luteal body. A prospective cohort Phase II study was performed in 24 women undergoing NC-IVF. Women underwent a reference cycle with human chorionic gonadotrophin-induced ovulation without follicle aspiration and analysis of the length of the luteal phase and luteal concentrations of progesterone and oestradiol. In addition, they underwent a NC-IVF cycle which was performed identically but follicles were aspirated and flushed three times. The luteal phase was shorter in 29.2%, equal in 16.7% and longer in 50.0% of cases following flushing of the follicles. Overall, neither difference in luteal phase length was significant [median duration (interquartile range) in reference cycle: 13 (12; 14.5), IVF (flushing) cycle: 14 (12.5; 14.5), median difference (95% CI): 0.5 (-0.5 to 1.5)] nor median progesterone and oestradiol concentrations. In conclusion, follicular flushing in NC-IVF affects neither the length of the luteal phase nor the luteal phase concentrations of progesterone and oestradiol, questioning the need for luteal phase supplementation.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

von Wolff, Michael, Kohl, Alexandra Sabrina, Stute, Petra, Fäh, Monika, Otti-Rosebrock, Gesa, Schürch, Roger, Rohner, Susanne


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Monika Zehr

Date Deposited:

07 Feb 2018 16:27

Last Modified:

20 Feb 2024 14:17

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Follicular flushing Luteal phase Luteal phase supplementation Natural cycle IVF Oestradiol Progesterone




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