Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part I: Indications for fertility preservation.

Schüring, A N; Fehm, T; Behringer, K; Goeckenjan, M; Wimberger, P; Henes, M; Henes, J; Fey, Martin; von Wolff, Michael (2018). Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part I: Indications for fertility preservation. Archives of gynecology and obstetrics, 297(1), pp. 241-255. Springer 10.1007/s00404-017-4594-3

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PURPOSE

Most guidelines about fertility preservation are predominantly focused on scientific evidence, but are less practically orientated. Therefore, practically oriented recommendations are needed to support the clinician in daily practice.

METHODS

A selective literature search was performed based on the clinical and scientific experience of the authors, focussing on the most relevant diseases and gynaecological cancers. This article (Part I) provides information on topics that are essential for the fertility preservation indication, such as disease prognosis, disease therapy and its associated risks to fertility, recommending disease-specific fertility preservation measures. Part II specifically focusses on fertility preservation techniques.

RESULTS

In breast cancer patients, fertility preservation such as ovarian tissue and oocyte cryopreservation is especially recommended in low-stage cancer and in women < 35 years of age. In Hodgkin's lymphoma, the indication is mainly based on the chemotherapy regime as some therapies have very low, others very high gonadotoxicity. In borderline ovarian tumours, preservation of fertility usually is achieved through fertility sparing surgery, ovarian stimulation may also be considered. In cervical cancer, endometrial cancer, rheumatic diseases and other malignancies such as Ewing sarcoma, colorectal carcinoma, non-Hodgkin lymphoma, leukaemia etc., several other factors must be considered to enable an individual, stage-dependent decision.

CONCLUSION

The decision for or against fertility preservation depends on the prognosis, the risks to fertility and individual factors such as prospective family planning.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Fey, Martin and von Wolff, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0932-0067

Publisher:

Springer

Language:

English

Submitter:

Monika Zehr

Date Deposited:

09 Feb 2018 15:41

Last Modified:

23 Feb 2021 19:24

Publisher DOI:

10.1007/s00404-017-4594-3

PubMed ID:

29177593

Uncontrolled Keywords:

Borderline ovarian tumour Breast cancer Cervical cancer Fertility preservation Hodgkin’s lymphoma Rheumatic diseases

BORIS DOI:

10.7892/boris.111206

URI:

https://boris.unibe.ch/id/eprint/111206

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