Heinrich, Daniel; Bektic, Jasmin; Bergman, Andries M; Caffo, Orazio; Cathomas, Richard; Chi, Kim N; Daugaard, Gedske; Keizman, Daniel; Kindblom, Jon; Kramer, Gero; Olmos, David; Omlin, Aurelius Gabriel; Sridhar, Srikala S; Tucci, Marcello; van Oort, Inge; Nilsson, Sten (2018). The Contemporary Use of Radium-223 in Metastatic Castration-resistant Prostate Cancer. Clinical genitourinary cancer, 16(1), e223-e231. Elsevier 10.1016/j.clgc.2017.08.020
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Radium-223 dichloride (radium-223) was approved for the treatment of patients with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases in the United States and Europe in 2013. This followed a reported overall survival benefit for patients treated with radium-223 and best standard of care (BSoC) when compared with placebo and BSoC in the ALpharadin in SYMptomatic Prostate CAncer (ALSYMPCA) trial. At that time, docetaxel was the standard first-line choice for patients with metastatic CRPC (mCRPC). Since then, the treatment landscape has changed dramatically with new hormonal agents (abiraterone and enzalutamide) considered to be the first-line choice for many patients. The optimal patient profile for radium-223 in the modern setting, and its best use either in sequence or in combination with other approved agents are unclear, with few definitive guidelines available. This article reports on the views of a group of urologists and medical oncologists experienced in treating patients with mCRPC with radium-223 in routine clinical practice. The aim is to provide an overview of the current use of radium-223 in the treatment of patients with mCRPC, and to discuss best practices for patient selection and on-treatment monitoring. Where agreement was reached, guidance on the optimal use of radium-223 is provided.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Omlin, Aurelius Gabriel |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1558-7673 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Nicole Corminboeuf |
Date Deposited: |
12 Mar 2018 14:56 |
Last Modified: |
05 Dec 2022 15:10 |
Publisher DOI: |
10.1016/j.clgc.2017.08.020 |
PubMed ID: |
29079165 |
Uncontrolled Keywords: |
Bone metastases Patient selection Targeted alpha therapy Treatment monitoring Treatment sequence |
BORIS DOI: |
10.7892/boris.111219 |
URI: |
https://boris.unibe.ch/id/eprint/111219 |
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