ICAMs support B cell interactions with T follicular helper cells and promote clonal selection.

Zaretsky, Irina; Atrakchi, Ofir; Mazor, Roei D; Stoler-Barak, Liat; Biram, Adi; Feigelson, Sara W; Gitlin, Alexander D; Engelhardt, Britta; Shulman, Ziv (2017). ICAMs support B cell interactions with T follicular helper cells and promote clonal selection. The Journal of experimental medicine, 214(11), pp. 3435-3448. Rockefeller Univ. Press 10.1084/jem.20171129

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Text 3435.full.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-Share Alike (CC-BY-NC-SA). © 2017 Zaretsky et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org /terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial– Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/) Download (2MB) | Preview

The germinal center (GC) reaction begins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and antigen presentation to the Tfh cells. How long-lasting T-B interactions and B cell clonal expansion are regulated by antigen presentation remains unclear. Here, we use in vivo B cell competition models and intravital imaging to examine the adhesive mechanisms governing B cell selection for GC colonization. We find that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate Tfh-B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion. Thus, B cell ICAMs promote efficient antibody immune response by enhancement of T cell help to cognate B cells.

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