The movers and shapers in immune privilege of the CNS.

Engelhardt, Britta; Vajkoczy, Peter; Weller, Roy O (2017). The movers and shapers in immune privilege of the CNS. Nature immunology, 18(2), pp. 123-131. Nature Publishing Group 10.1038/ni.3666

	Text ni.3666.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (15MB)
	Text ni.3666.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (15MB)

Discoveries leading to an improved understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked dismissal of the existence of immune privilege of the CNS. Recent rediscoveries of lymphatic vessels within the dura mater surrounding the brain, made possible by modern live-cell imaging technologies, have revived this discussion. This review emphasizes the fact that understanding immune privilege of the CNS requires intimate knowledge of its unique anatomy. Endothelial, epithelial and glial brain barriers establish compartments in the CNS that differ strikingly with regard to their accessibility to immune-cell subsets. There is a unique system of lymphatic drainage from the CNS to the peripheral lymph nodes. We summarize current knowledge on the cellular and molecular mechanisms involved in immune-cell trafficking and lymphatic drainage from the CNS, and we take into account differences in rodent and human CNS anatomy.

Interest & Impact

Downloads

13 since deposited on 27 Feb 2018
1 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item