Colorectal cancer: epigenetic alterations and their clinical implications.

Puccini, Alberto; Berger, Martin Dave; Naseem, Madiha; Tokunaga, Ryuma; Battaglin, Francesca; Cao, Shu; Hanna, Diana L; McSkane, Michelle; Soni, Shivani; Zhang, Wu; Lenz, Heinz-Josef (2017). Colorectal cancer: epigenetic alterations and their clinical implications. Biochimica et biophysica acta, 1868(2), pp. 439-448. Elsevier 10.1016/j.bbcan.2017.09.003

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Colorectal cancer (CRC) is a heterogeneous disease with distinct molecular and clinical features, which reflects the wide range of prognostic outcomes and treatment responses observed among CRC patients worldwide. Our understanding of the CRC epigenome has been largely developed over the last decade and it is now believed that among thousands of epigenetic alterations present in each tumor, a small subgroup of these may be considered as a CRC driver event. DNA methylation profiles have been the most widely studied in CRC, which includes a subset of patients with distinct molecular and clinical features now categorized as CpG island methylator phenotype (CIMP). Major advances have been made in our capacity to detect epigenetic alterations, providing us with new potential biomarkers for diagnostic, prognostic and therapeutic purposes. This review aims to summarize our current knowledge about epigenetic alterations occurring in CRC, underlying their potential future clinical implications in terms of diagnosis, prognosis and therapeutic strategies for CRC patients.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Berger, Martin Dave

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0006-3002

Publisher:

Elsevier

Language:

English

Submitter:

Nicole Corminboeuf

Date Deposited:

26 Mar 2018 14:04

Last Modified:

29 Oct 2019 04:40

Publisher DOI:

10.1016/j.bbcan.2017.09.003

PubMed ID:

28939182

Uncontrolled Keywords:

Biomarkers CIMP Colorectal cancer Epigenetic alterations Prognosis Treatment

BORIS DOI:

10.7892/boris.111366

URI:

https://boris.unibe.ch/id/eprint/111366

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