Efficacy of antidepressants over placebo is similar in two-armed versus three-armed or more-armed randomized placebo-controlled trials.

Ogawa, Yusuke; Furukawa, Toshi A; Takeshima, Nozomi; Hayasaka, Yu; Atkinson, Lauren Z; Tanaka, Shiro; Cipriani, Andrea; Salanti, Georgia (2018). Efficacy of antidepressants over placebo is similar in two-armed versus three-armed or more-armed randomized placebo-controlled trials. International clinical psychopharmacology, 33(2), pp. 66-72. Wolters Kluwer Lippincott Williams & Wilkins 10.1097/YIC.0000000000000201

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Previous studies have reported that effect sizes of antidepressants were larger in two-armed than in three-armed or more-armed (multiarmed) randomized trials, where the probability of being allocated to placebo is lower. However, these studies have not taken into account the publication bias, differences among antidepressants, or covariance in multiarmed studies, or examined sponsorship bias. We searched published and unpublished randomized-controlled trials that compared placebo with 21 antidepressants for the acute treatment of major depression in adults. We calculated the ratio of odds ratios (ROR) of drug response over placebo in two-armed versus multiarmed trials for each antidepressant, and then synthesized RORs across all the included antidepressants using the multivariate meta-analysis. A random-effects model was used throughout. Two hundred and fifty-eight trials (66 two-armed and 192 multiarmed trials; 80 454 patients; 43.0% with unpublished data) were included in the present analyses. The pooled ROR for response of two-armed trials over multiarmed trials was 1.09 (95% confidence interval: 0.96-1.24). The ROR did not materially change between types of antidepressants, publication year, or sponsorship. The differences between two-armed versus multiarmed studies were much smaller than were suggested in previous studies and were not significant.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Salanti, Georgia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1473-5857

Publisher:

Wolters Kluwer Lippincott Williams & Wilkins

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

15 Feb 2018 14:46

Last Modified:

24 Oct 2019 08:36

Publisher DOI:

10.1097/YIC.0000000000000201

PubMed ID:

29064911

BORIS DOI:

10.7892/boris.111386

URI:

https://boris.unibe.ch/id/eprint/111386

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