New Challenges in Aortic Stenosis in the Elderly: From Epidemiology to TAVI

Schoenenberger, Andreas; Martínez-Sellés, Manuel (2017). New Challenges in Aortic Stenosis in the Elderly: From Epidemiology to TAVI. In: Ungar, Andrea; Marchionni, Niccolò (eds.) Cardiac Management in the Frail Elderly Patient and the Oldest Old (pp. 105-111). Springer 10.1007/978-3-319-43468-1_9

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There are three principal causes of valvular aortic stenosis (AS): congenital, rheumatic, and degenerative. While congenital AS clinically manifests at younger ages and rheumatic AS dwindled in importance with the decline in rheumatic fever, age-related degenerative calcific AS is now the most common cause of valvular AS in adults [1]. Degenerative calcific AS is the result of a progressive calcification of the aortic valves based on a process of inflammation, lipid accumulation, and calcification. This dynamic process resembles the process of atherosclerosis in many regards. Some clinical risk factors of atherosclerosis have also been identified as risk factors of calcific AS, including hypertension, hyperlipidemia, smoking, and diabetes [2]. Degenerative calcific AS occurs in patients with congenitally normal tricuspid aortic valves, but a congenitally bicuspid aortic valve seems to be an important additional risk factor of degenerative calcific AS development [1, 3].

Item Type:

Book Section (Book Chapter)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Geriatric Clinic

UniBE Contributor:

Schoenenberger, Andreas


600 Technology > 610 Medicine & health








Rebecca Rufer

Date Deposited:

27 Feb 2018 10:21

Last Modified:

27 Feb 2018 10:21

Publisher DOI:



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