Confidence intervals for differences between volumes under receiver operating characteristic surfaces (VUS) and generalized Youden indices (GYIs)

Yin, Jingjing; Nakas, Christos T.; Tian, Lili; Reiser, Benjamin (2017). Confidence intervals for differences between volumes under receiver operating characteristic surfaces (VUS) and generalized Youden indices (GYIs). Statistical Methods in Medical Research, 27(3), pp. 675-688. SAGE Publications (UK and US) 10.1177/0962280217740787

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This article explores both existing and new methods for the construction of confidence intervals for differences of indices of diagnostic accuracy of competing pairs of biomarkers in three-class classification problems and fills the methodological gaps for both parametric and non-parametric approaches in the receiver operating characteristic surface framework. The most widely used such indices are the volume under the receiver operating characteristic surface and the generalized Youden index. We describe implementation of all methods and offer insight regarding the appropriateness of their use through a large simulation study with different distributional and sample size scenarios. Methods are illustrated using data from the Alzheimer's Disease Neuroimaging Initiative study, where assessment of cognitive function naturally results in a three-class classification setting.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Nakas, Christos T.

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0962-2802

Publisher:

SAGE Publications (UK and US)

Language:

English

Submitter:

Marie-Christine Müller

Date Deposited:

12 Mar 2018 16:55

Last Modified:

27 Oct 2019 06:33

Publisher DOI:

10.1177/0962280217740787

PubMed ID:

29233075

BORIS DOI:

10.7892/boris.111413

URI:

https://boris.unibe.ch/id/eprint/111413

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