Imepitoin is well tolerated in healthy and epileptic cats.

Engel, O; von Klopmann, T; Maiolini, Arianna; Freundt-Revilla, J; Tipold, A (2017). Imepitoin is well tolerated in healthy and epileptic cats. BMC veterinary research, 13(1), p. 172. BioMed Central 10.1186/s12917-017-1087-3

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Abstract BACKGROUND: Epilepsy in the cat is a serious medical condition. To date there are no licensed treatments for feline epilepsy and no well-controlled clinical studies on the efficacy or safety of antiepileptic drugs in cats. The aim of this study was to collect tolerability data and first exploratory efficacy data of imepitoin in both healthy and epileptic cats. RESULTS: In two tolerability studies, 30 healthy cats received imepition twice daily in doses of 0, 30, 40 or 80 mg/kg bodyweight for 30 days. No serious adverse events were observed in any of the dose groups. In the imepitoin treated groups, emesis was observed in some animals temporarily and intermittently mainly in the second and third weeks of treatment. In a small, single-arm, open label, uncontrolled clinical trial eight cats suffering from idiopathic epilepsy were treated with imepitoin twice daily at doses of 30 mg/kg bodyweight for 30 days. Four of these cats (50%) achieved seizure freedom for at least 8 weeks under treatment. Adverse events, mostly lethargy, decreased appetite and emesis, were often mild and transient. CONCLUSION: In summary, imepitoin was well tolerated in healthy and epileptic cats and showed in a pilot trial indication for efficacy in treating feline epilepsy.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Research Foci > NeuroCenter
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Maiolini, Arianna

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

1746-6148

Publisher:

BioMed Central

Language:

English

Submitter:

Veronika Maria Stein

Date Deposited:

03 May 2018 15:27

Last Modified:

23 Oct 2019 20:30

Publisher DOI:

10.1186/s12917-017-1087-3

PubMed ID:

28606140

BORIS DOI:

10.7892/boris.111449

URI:

https://boris.unibe.ch/id/eprint/111449

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