Dynamics of Bile Acid Profiles, GLP-1, and FGF19 After Laparoscopic Gastric Banding.

Thöni, Veronika; Pfister, Alexandra; Melmer, Andreas; Enrich, Barbara; Salzmann, Karin; Kaser, Susanne; Lamina, Claudia; Ebenbichler, Christoph F; Hackl, Hubert; Tilg, Herbert; Moschen, Alexander R (2017). Dynamics of Bile Acid Profiles, GLP-1, and FGF19 After Laparoscopic Gastric Banding. The Journal of clinical endocrinology and metabolism, 102(8), pp. 2974-2984. The Endocrine Society 10.1210/jc.2017-00235

Full text not available from this repository.

Context

An increase of bile acids (BAs), fibroblast growth factor 19 (FGF19), and glucagon-like peptide 1 (GLP-1) has been implicated in metabolic improvements after Roux-en-Y gastric bypass and vertical sleeve gastrectomy. However, data are still conflicting regarding their role after laparoscopic adjustable gastric banding (LAGB).

Objective

To assess the fasting BA, FGF19, and GLP-1 concentrations in plasma before and after LAGB and to test for correlations with immunometabolic parameters. Furthermore, hepatic farnesoid X receptor (FXR) expression and regulation of FXR-dependent genes were analyzed.

Design and Setting

Observational study at the University Hospital Innsbruck.

Patients

Twenty obese patients.

Interventions

Fasting plasma samples were taken before, 3, 6, and 12 months after LAGB. Liver biopsies were obtained at surgery and after 6 months postoperatively.

Main Outcome Measures

BA profiles, GLP-1 and FGF19 levels, hepatic FXR expression and regulation of FXR target genes were determined.

Results

Total, conjugated, and secondary BAs transiently increased 3 months after LAGB (P < 0.01). Only one BA, glycolithocholic acid sulfate, remained significantly elevated throughout the whole follow-up period (P < 0.05). GLP-1 had increased transiently 3 months after surgery (P < 0.01), whereas FGF19 levels increased continuously (P < 0.05). Insulin, homeostasis model assessment index, C-reactive protein, FGF19, and GLP-1 correlated positively with different BAs. No differences were seen in hepatic FXR expression and FXR-regulated genes.

Conclusions

Our study results, not only identified LAGB-induced changes in BAs and BA-induced hormones, but also revealed associations between changes in BA profile with GLP-1 and FGF19.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
UniBE Contributor:	Melmer, Andreas
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1945-7197
Publisher:	The Endocrine Society
Language:	English
Submitter:	Andreas Melmer
Date Deposited:	22 Feb 2018 10:32
Last Modified:	05 Dec 2022 15:10
Publisher DOI:	10.1210/jc.2017-00235
PubMed ID:	28591793
URI:	https://boris.unibe.ch/id/eprint/111478