Thöni, Veronika; Pfister, Alexandra; Melmer, Andreas; Enrich, Barbara; Salzmann, Karin; Kaser, Susanne; Lamina, Claudia; Ebenbichler, Christoph F; Hackl, Hubert; Tilg, Herbert; Moschen, Alexander R (2017). Dynamics of Bile Acid Profiles, GLP-1, and FGF19 After Laparoscopic Gastric Banding. The Journal of clinical endocrinology and metabolism, 102(8), pp. 2974-2984. The Endocrine Society 10.1210/jc.2017-00235
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An increase of bile acids (BAs), fibroblast growth factor 19 (FGF19), and glucagon-like peptide 1 (GLP-1) has been implicated in metabolic improvements after Roux-en-Y gastric bypass and vertical sleeve gastrectomy. However, data are still conflicting regarding their role after laparoscopic adjustable gastric banding (LAGB).
Objective
To assess the fasting BA, FGF19, and GLP-1 concentrations in plasma before and after LAGB and to test for correlations with immunometabolic parameters. Furthermore, hepatic farnesoid X receptor (FXR) expression and regulation of FXR-dependent genes were analyzed.
Design and Setting
Observational study at the University Hospital Innsbruck.
Patients
Twenty obese patients.
Interventions
Fasting plasma samples were taken before, 3, 6, and 12 months after LAGB. Liver biopsies were obtained at surgery and after 6 months postoperatively.
Main Outcome Measures
BA profiles, GLP-1 and FGF19 levels, hepatic FXR expression and regulation of FXR target genes were determined.
Results
Total, conjugated, and secondary BAs transiently increased 3 months after LAGB (P < 0.01). Only one BA, glycolithocholic acid sulfate, remained significantly elevated throughout the whole follow-up period (P < 0.05). GLP-1 had increased transiently 3 months after surgery (P < 0.01), whereas FGF19 levels increased continuously (P < 0.05). Insulin, homeostasis model assessment index, C-reactive protein, FGF19, and GLP-1 correlated positively with different BAs. No differences were seen in hepatic FXR expression and FXR-regulated genes.
Conclusions
Our study results, not only identified LAGB-induced changes in BAs and BA-induced hormones, but also revealed associations between changes in BA profile with GLP-1 and FGF19.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Melmer, Andreas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1945-7197 |
Publisher: |
The Endocrine Society |
Language: |
English |
Submitter: |
Andreas Melmer |
Date Deposited: |
22 Feb 2018 10:32 |
Last Modified: |
05 Dec 2022 15:10 |
Publisher DOI: |
10.1210/jc.2017-00235 |
PubMed ID: |
28591793 |
URI: |
https://boris.unibe.ch/id/eprint/111478 |
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