Effect of preoperative immunonutrition on postoperative short-term outcomes of patients with head and neck squamous cell carcinoma.

Aeberhard, Carla; Mayer, Catherine; Meyer, Simone; Mueller, Simon Andreas; Schuetz, Philipp; Stanga, Zeno; Giger, Roland (2018). Effect of preoperative immunonutrition on postoperative short-term outcomes of patients with head and neck squamous cell carcinoma. Head & neck - journal for the sciences and specialties of the head and neck, 40(5), pp. 1057-1067. J. Wiley 10.1002/hed.25072

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BACKGROUND Patients with head and neck squamous cell carcinoma (HNSCC) often acquire an impaired nutritional status resulting in compromised outcomes. Perioperative immunonutrition may have a positive effect on outcomes after elective surgery. METHODS Short-term outcomes before and after implementation of preoperative immunonutrition were retrospectively assessed. Regression models adjusted for outcome predictors were used to compare the length of stay (LOS) in the hospital, local infections, and general complications. RESULTS Four hundred eleven patients were included (control group = 209 and the intervention group = 202). With immunonutrition, hospital LOS was significantly lower (median 6 vs 8 days; adjusted mean difference of -5.65 days; P < .001) and local infections were significantly reduced (7.4% vs 15.3%; adjusted odds ratio [OR] 0.30; P = .006). Subgroup analysis showed more pronounced effects in patients with previous radiotherapy and extensive surgery. CONCLUSION Patients receiving preoperative immunonutrition had a shorter hospital LOS and a lower rate for wound infections and local complications. These effects remained robust after a multivariate adjustment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Aeberhard, Carla and Stanga, Zeno

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1043-3074

Publisher:

J. Wiley

Language:

English

Submitter:

Andreas Melmer

Date Deposited:

22 Feb 2018 12:35

Last Modified:

25 Apr 2018 01:31

Publisher DOI:

10.1002/hed.25072

PubMed ID:

29368455

Uncontrolled Keywords:

head and neck cancer head and neck surgery immunonutrition length of hospital stay wound infections

BORIS DOI:

10.7892/boris.111486

URI:

https://boris.unibe.ch/id/eprint/111486

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