Acute kidney injury in symptomatic primary Epstein-Barr virus infectious mononucleosis: Systematic review.

Moretti, Milena; Lava, Sebastiano; Zgraggen, Lorenzo; Simonetti, Giacomo; Kottanattu, Lisa; Bianchetti, Mario Giovanni; Milani, Gregorio P (2017). Acute kidney injury in symptomatic primary Epstein-Barr virus infectious mononucleosis: Systematic review. Journal of clinical virology, 91, pp. 12-17. Elsevier 10.1016/j.jcv.2017.03.016

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BACKGROUND AND OBJECTIVES

Textbooks and reviews do not mention the association of symptomatic primary Epstein-Barr virus infectious mononucleosis with acute kidney injury in subjects without immunodeficiency or autoimmunity.

STUDY DESIGN

Stimulated by our experience with two cases, we performed a review of the literature.

RESULTS

The literature documents 38 cases (26 male and 12 female individuals ranging in age from 0.3 to 51, median 18 years) of symptomatic primary Epstein-Barr virus infectious mononucleosis complicated by acute kidney injury: 27 acute interstitial nephritides, 1 jaundice-associated nephropathy, 7 myositides and 3 hemolytic uremic syndromes. Acute kidney injury requiring renal replacement therapy was observed in 18 (47%) cases. Acute kidney injury did not resolve in one patient with acute interstitial nephritis. Two patients died because of systemic complications. The remaining 35 cases fully recovered.

CONCLUSIONS

In individuals with acute symptomatic Epstein-Barr virus infectious mononucleosis, a relevant kidney injury is rare but the outcome potentially fatal. It results from interstitial nephritis, myositis-associated acute kidney injury, hemolytic uremic syndrome or jaundice-associated nephropathy.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Lava, Sebastiano; Zgraggen, Lorenzo; Simonetti, Giacomo; Kottanattu, Lisa and Bianchetti, Mario Giovanni

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1386-6532

Publisher:

Elsevier

Language:

English

Submitter:

Dr. Sebastiano A.G. Lava

Date Deposited:

28 Mar 2018 14:19

Last Modified:

25 Oct 2019 09:05

Publisher DOI:

10.1016/j.jcv.2017.03.016

PubMed ID:

28410496

Uncontrolled Keywords:

Acute kidney injury Epstein-Barr virus infections Hemolytic-uremic syndrome Interstitial Myositis Nephritis

BORIS DOI:

10.7892/boris.111746

URI:

https://boris.unibe.ch/id/eprint/111746

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