Protoparvovirus Cell Entry.

Ros Bascunana, Carlos; Bayat, Nooshin; Wolfisberg, Raphael; Almendral, José M (2017). Protoparvovirus Cell Entry. Viruses, 9(11) Molecular Diversity Preservation International MDPI 10.3390/v9110313

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The(PtPV) genus of thefamily of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities while being nonpathogenic for humans. The PtPVs invade and replicate within the nucleus making extensive use of the transport, transcription and replication machineries of the host cells. In order to reach the nucleus, PtPVs need to cross over several intracellular barriers and traffic through different cell compartments, which limit their infection efficiency. In this review we summarize molecular interactions, capsid structural transitions and hijacking of cellular processes, by which the PtPVs enter and deliver their single-stranded DNA genome into the host cell nucleus. Understanding mechanisms that govern the complex PtPV entry will be instrumental in developing approaches to boost their anticancer therapeutic potential and improving their safety profile.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Ros Bascunana, Carlos

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1999-4915

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Carlos Ros Bascunana

Date Deposited:

03 May 2018 15:23

Last Modified:

24 Oct 2019 19:19

Publisher DOI:

10.3390/v9110313

PubMed ID:

29072600

Uncontrolled Keywords:

Protoparvovirus capsid rearrangements endosomal escape icosahedral capsid nuclear import parvovirus receptor binding trafficking signals virus entry

BORIS DOI:

10.7892/boris.111758

URI:

https://boris.unibe.ch/id/eprint/111758

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