Patency of the arterial pedal-plantar arch in patients with chronic kidney disease or diabetes mellitus.

Haine, Axel; Haynes, Alan; Limacher, Andreas; Sebastian, Tim; Saengprakai, Wuttichai; Fuss, Torsten; Baumgartner, Iris (2018). Patency of the arterial pedal-plantar arch in patients with chronic kidney disease or diabetes mellitus. Therapeutic advances in cardiovascular disease, 12(5), pp. 145-153. Sage 10.1177/1753944718756605

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BACKGROUND Patency of the pedal-plantar arch limits risk of amputation in peripheral artery disease (PAD). We examined patients without chronic kidney disease (CKD)/diabetes mellits (DM) [PAD-control], those with DM without CKD, and those with CKD without DM. METHOD Uni- and multivariate logistic regression was used to assess association of CKD with loss of patency of the pedal-plantar arch and presence of tibial or peroneal vessel occlusion. Multivariate models adjusted for age, sex, hypertension, hyperlipidemia and smoking. RESULTS A total of 419 patients were included [age 75.2 ± 10.3 years, 288 (69%) male]. CKD nearly doubled the unadjusted odds ratio (OR) for loss of patency of the pedal-plantar arch. After adjustment, association remained significant for severe CKD [estimated glomerular filtration rate (eGFR) ≤ 29 ml/min compared with eGFR ≥ 60 ml/min, adjusted (adj.) OR 8.24 (95% confidence interval {CI} 0.99-68.36, p = 0.05)]. CKD was not related to risk of tibial or peroneal artery occlusion [PAD-control versus CKD, adj. OR 1.09 (95% CI 0.49-2.44, p = 0.83)] in contrast to DM [PAD-control versus DM, adj. OR 2.41 (95% CI 1.23-4.72, p = 0.01), CKD versus DM, adj. OR 2.21 (95% CI 0.93-5.22); p = 0.07)]. CONCLUSIONS Below the knee (BTK) vascular pattern differs in patients with either DM or CKD alone. Severe CKD is a risk factor for loss of patency of the pedal-plantar arch.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie

UniBE Contributor:

Haine, Axel; Haynes, Alan; Limacher, Andreas and Baumgartner, Iris

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1753-9447

Publisher:

Sage

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

08 Mar 2018 22:23

Last Modified:

10 Jan 2019 12:03

Publisher DOI:

10.1177/1753944718756605

PubMed ID:

29431578

Uncontrolled Keywords:

atherosclerosis chronic kidney disease diabetes mellitus peripheral arterial disease

BORIS DOI:

10.7892/boris.112026

URI:

https://boris.unibe.ch/id/eprint/112026

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