Integrated field, laboratory, and theoretical study of PKD spread in a Swiss prealpine river.

Carraro, Luca; Bertuzzo, Enrico; Mari, Lorenzo; Fontes, Inês; Hartikainen, Hanna; Strepparava, Nicole; Schmidt-Posthaus, Heike; Wahli, Thomas; Jokela, Jukka; Gatto, Marino; Rinaldo, Andrea (2017). Integrated field, laboratory, and theoretical study of PKD spread in a Swiss prealpine river. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 114(45), pp. 11992-11997. National Academy of Sciences NAS 10.1073/pnas.1713691114

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Proliferative kidney disease (PKD) is a major threat to wild and farmed salmonid populations because of its lethal effect at high water temperatures. Its causative agent, the myxozoan, has a complex lifecycle exploiting freshwater bryozoans as primary hosts and salmonids as secondary hosts. We carried out an integrated study of PKD in a prealpine Swiss river (the Wigger). During a 3-year period, data on fish abundance, disease prevalence, concentration of primary hosts' DNA in environmental samples [environmental DNA (eDNA)], hydrological variables, and water temperatures gathered at various locations within the catchment were integrated into a newly developed metacommunity model, which includes ecological and epidemiological dynamics of fish and bryozoans, connectivity effects, and hydrothermal drivers. Infection dynamics were captured well by the epidemiological model, especially with regard to the spatial prevalence patterns. PKD prevalence in the sampled sites for both young-of-the-year (YOY) and adult brown trout attained 100% at the end of summer, while seasonal population decay was higher in YOY than in adults. We introduce a method based on decay distance of eDNA signal predicting local species' density, accounting for variation in environmental drivers (such as morphology and geology). The model provides a whole-network overview of the disease prevalence. In this study, we show how spatial and environmental characteristics of river networks can be used to study epidemiology and disease dynamics of waterborne diseases.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Strepparava, Nicole; Schmidt-Posthaus, Heike and Wahli, Thomas

Subjects:

600 Technology > 630 Agriculture

ISSN:

0027-8424

Publisher:

National Academy of Sciences NAS

Language:

English

Submitter:

Lucia Gugger-Raaflaub

Date Deposited:

08 May 2018 11:48

Last Modified:

25 Oct 2019 14:00

Publisher DOI:

10.1073/pnas.1713691114

PubMed ID:

29078391

Uncontrolled Keywords:

climate change eDNA metacommunity framework parasite–host interactions waterborne epidemic

BORIS DOI:

10.7892/boris.112093

URI:

https://boris.unibe.ch/id/eprint/112093

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