A role for multiple estrogen receptors in immune regulation of common carp.

Szwejser, Ewa; Maciuszek, Magdalena; Casanova, Ayako; Segner, Helmut; Verburg-van Kemenade, B M Lidy; Chadzinska, Magdalena (2017). A role for multiple estrogen receptors in immune regulation of common carp. Developmental and Comparative Immunology, 66, pp. 61-72. Elsevier 10.1016/j.dci.2016.04.003

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Estrogens are important for bi-directional neuroendocrine-immune interaction. They act via nuclear estrogen receptors (ERα and ERβ) and/or G-protein coupled receptor - GPR30. We found expression of ERα, ERβ and GPR30 in carp lymphoid tissues and head kidney monocytes/macrophages, neutrophils and lymphocytes. Interestingly, ERβ is also expressed in some head kidney lymphocytes but not in naive PBLs. Immune stimulation altered the cell type specific profile of expression of these receptors, which depends on both activation and maturation stage. This implies direct leukocyte responsiveness to estrogen stimulation and therefore in vitro effects of 17β-estradiol (E2) on reactive oxygen species (ROS) production in monocytes/macrophages were determined. Short-time incubation with E2 increased ROS production in PMA-stimulated cells. Results comply with mediation by GPR30, partially functioning via phosphoinositide 3-kinase activation. These results furthermore demonstrate that neuroendocrine-immune communication via estrogen receptors is evolutionary conserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Casanova, Ayako and Segner, Helmut

Subjects:

600 Technology > 630 Agriculture

ISSN:

0145-305X

Publisher:

Elsevier

Language:

English

Submitter:

Lucia Gugger-Raaflaub

Date Deposited:

08 May 2018 14:06

Last Modified:

08 May 2018 14:15

Publisher DOI:

10.1016/j.dci.2016.04.003

PubMed ID:

27062969

Uncontrolled Keywords:

17β-estradiol Carp Estrogen receptors GPR30 Immune response Monocyte/macrophage

BORIS DOI:

10.7892/boris.112107

URI:

https://boris.unibe.ch/id/eprint/112107

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