Dose-response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect?

Gillmann, Clarissa; Lomax, Antony J; Weber, Damien Charles; Jäkel, Oliver; Karger, Christian P (2018). Dose-response curves for MRI-detected radiation-induced temporal lobe reactions in patients after proton and carbon ion therapy: Does the same RBE-weighted dose lead to the same biological effect? Radiotherapy and oncology, 128(1), pp. 109-114. Elsevier 10.1016/j.radonc.2018.01.018

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PURPOSE

To derive the dose-response curve for temporal lobe reactions (TLRs) after proton therapy and to compare the resulting relative biological effectiveness (RBE)-weighted tolerance doses based on an RBE of 1.1 with published values for carbon ions, which were calculated by the two versions of the local effect model (LEM I or IV).

METHODS AND MATERIALS

62 patients treated with protons for skull base tumors were analyzed for TLRs using magnetic resonance imaging. Within the mean follow-up time of 38 months, TLRs were observed in six patients. Dose-response curves based on the RBE-weighted maximum dose, excluding the 1 cm-volume with the highest dose, were derived and compared to previously published dose-response curves for carbon ions, which were obtained using LEM I or IV, respectively.

RESULTS

The dose-response curves for protons and LEM I were found to be almost identical while the curve of LEM IV was shifted toward higher doses. The resulting tolerance doses at the 5% effect level were 68.2, 68.6and 78.3Gy (RBE), respectively.

CONCLUSIONS

The RBE-weighted dose prescription for protons leads to the same RBE-weighted dose-response curve for TLR as the one for LEM I-based carbon ions, while LEM IV predicts clinically significant higher tolerance doses.

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