Phase-dependent modulation of signal transmission in cortical networks through tACS-Induced neural oscillations

Fehér, Kristoffer Daniel; Nakataki, Masahito; Morishima, Yosuke (2017). Phase-dependent modulation of signal transmission in cortical networks through tACS-Induced neural oscillations. Frontiers in human neuroscience, 11(471), p. 471. Frontiers Research Foundation 10.3389/fnhum.2017.00471

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Oscillatory neural activity is considered a basis of signal transmission in brain networks. However, the causal role of neural oscillations in regulating cortico-cortical signal transmission has so far not been directly demonstrated. To date, due to methodological limitations, studies on the online modulatory mechanisms of transcranial alternating current stimulation (tACS)-induced neural oscillations are confined to the primary motor cortex. To address the causal role of oscillatory activity in modulating cortico-cortical signal transmission, we have established a new method using concurrent tACS, transcranial magnetic stimulation (TMS) and electroencephalography (EEG). Through tACS, we introduced 6-Hz (theta) oscillatory activity in the human dorsolateral prefrontal cortex (DLPFC). During tACS, we applied single-pulse TMS over the DLPFC at different phases of tACS and assessed propagation of TMS-induced neural activity with EEG. We show that tACS-induced theta oscillations modulate the propagation of TMS-induced activity in a phase-dependent manner and that phase-dependent modulation is not simply explained by the instantaneous amplitude of tACS. The results demonstrate a phase-dependent modulatory mechanism of tACS at a cortical network level, which is consistent with a causal role of neural oscillations in regulating the efficacy of signal transmission in the brain.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Fehér, Kristoffer Daniel and Morishima, Yosuke

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-5161

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Kristoffer Daniel Fehér

Date Deposited:

21 Mar 2018 13:03

Last Modified:

25 Mar 2018 03:21

Publisher DOI:

10.3389/fnhum.2017.00471

PubMed ID:

29021749

Web of Science ID:

000412016700001

BORIS DOI:

10.7892/boris.112275

URI:

https://boris.unibe.ch/id/eprint/112275

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