Patterns of non-syndromic permanent tooth agenesis in a large orthodontic population

Gkantidis, Nikolaos; Katib, Hattan Saud A; Oeschger, Elias Sebastian; Karamolegkou, M; Topouzelis, N; Kanavakis, G (2017). Patterns of non-syndromic permanent tooth agenesis in a large orthodontic population. Archives of oral biology, 79, pp. 42-47. Elsevier Science 10.1016/j.archoralbio.2017.02.020

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OBJECTIVE: The aim of this study is to explore patterns of non-syndromic permanent tooth agenesis in a large orthodontic patient group. DESIGN: A record review was performed in various orthodontic clinics to identify white patients with non-syndromic permanent tooth agenesis, excluding 3rd molars. Four hundred and fourteen subjects fulfilled the inclusion criteria. RESULTS: In the 414 subjects with tooth agenesis, approximately 70% presented 1-2 missing teeth. Symmetric agenesis patterns were often observed in the sample (by jaw, by side, or crossed quadrants), with prevalence approaching 30% for cases with contralateral tooth agenesis within a jaw. In cases with 1 or 2 missing teeth, from the total number of potential tooth agenesis patterns in the sample, a certain part was evident, limiting the variation to 27.8% (44/158). In the entire sample, both in the maxilla and the mandible a certain incisor/premolar agenesis phenotype was observed in 59.0% of cases in isolated form. CONCLUSIONS: Although there was variation in the tooth agenesis patterns, our findings suggest the involvement of particular genetic, epigenetic, and/or environmental factors in the formation of the entire dentition, which often lead to specific tooth agenesis phenotypes in cases where this process is disrupted. The present study provides a comprehensive categorization of orthodontic cases with tooth agenesis and can assist in planning future epidemiological and genetic studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics
04 Faculty of Medicine > School of Dental Medicine

UniBE Contributor:

Gkantidis, Nikolaos; Katib, Hattan Saud A and Oeschger, Elias Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0003-9969

Publisher:

Elsevier Science

Language:

English

Submitter:

Renate Imhof-Etter

Date Deposited:

27 Mar 2018 11:44

Last Modified:

27 Mar 2018 11:44

Publisher DOI:

10.1016/j.archoralbio.2017.02.020

PubMed ID:

28288390

Uncontrolled Keywords:

Non-syndromic, Orthodontic patients, Permanent dentition, Tooth agenesis

BORIS DOI:

10.7892/boris.112298

URI:

https://boris.unibe.ch/id/eprint/112298

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