Conservation of the RNA Transport Machineries and Their Coupling to Translation Control across Eukaryotes

Vazquez-Pianzola, Paula; Suter, Beat (2012). Conservation of the RNA Transport Machineries and Their Coupling to Translation Control across Eukaryotes. Comparative and functional genomics, 2012, p. 287852. New York, N.Y.: Hindawi 10.1155/2012/287852

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Restriction of proteins to discrete subcellular regions is a common mechanism to establish cellular asymmetries and depends on a coordinated program of mRNA localization and translation control. Many processes from the budding of a yeast to the establishment of metazoan embryonic axes and the migration of human neurons, depend on this type of cell polarization. How factors controlling transport and translation assemble to regulate at the same time the movement and translation of transported mRNAs, and whether these mechanisms are conserved across kingdoms is not yet entirely understood. In this review we will focus on some of the best characterized examples of mRNA transport machineries, the "yeast locasome" as an example of RNA transport and translation control in unicellular eukaryotes, and on the Drosophila Bic-D/Egl/Dyn RNA localization machinery as an example of RNA transport in higher eukaryotes. This focus is motivated by the relatively advanced knowledge about the proteins that connect the localizing mRNAs to the transport motors and the many well studied proteins involved in translational control of specific transcripts that are moved by these machineries. We will also discuss whether the core of these RNA transport machineries and factors regulating mRNA localization and translation are conserved across eukaryotes.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Suter, Beat

ISSN:

1531-6912

Publisher:

Hindawi

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:30

Last Modified:

22 Dec 2014 21:29

Publisher DOI:

10.1155/2012/287852

PubMed ID:

22666086

Web of Science ID:

000304945800001

BORIS DOI:

10.7892/boris.11235

URI:

https://boris.unibe.ch/id/eprint/11235 (FactScience: 217301)

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