Effectors Targeting Host Signaling and Transcription.

Hakimi, Mohamed-Ali; Olias, Philipp Alexander; Sibley, L David (2017). Effectors Targeting Host Signaling and Transcription. Clinical microbiology reviews, 30(3), pp. 615-645. American Society for Microbiology ASM 10.1128/CMR.00005-17

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Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during invasion of host cells. These early morphological studies were followed by the exploration of the cellular contents of these secretory organelles, revealing them to be comprised of highly divergent protein families with few conserved domains or predicted functions. In parallel, studies on host-pathogen interactions identified many host signaling pathways that were mysteriously altered by infection. It was only with the advent of forward and reverse genetic strategies that the connections between individual parasite effectors and the specific host pathways that they targeted finally became clear. The current repertoire of parasite effectors includes ROP kinases and pseudokinases that are secreted during invasion and that block host immune pathways. Similarly, many secretory GRA proteins alter host gene expression by activating host transcription factors, through modification of chromatin, or by inducing small noncoding RNAs. These effectors highlight novel mechanisms by whichhas learned to harness host signaling to favor intracellular survival and will guide future studies designed to uncover the additional complexity of this intricate host-pathogen interaction.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Olias, Philipp Alexander

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

0893-8512

Publisher:

American Society for Microbiology ASM

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

08 May 2018 16:00

Last Modified:

05 Nov 2019 06:16

Publisher DOI:

10.1128/CMR.00005-17

PubMed ID:

28404792

Uncontrolled Keywords:

chromatin remodeling epigenetics immune evasion innate immunity intracellular pathogen serine/threonine kinases signal transduction transcription factors

BORIS DOI:

10.7892/boris.112388

URI:

https://boris.unibe.ch/id/eprint/112388

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