Hyaluronic Acid as an Adjunct After Scaling and Root Planing - A Prospective Randomized Clinical Trial

Eick, Sigrun; Renatus, Antonio; Heinicke, Melanie; Pfister, Wolfgang; Stratul, Stefan-Ioan; Jentsch, Holger (2013). Hyaluronic Acid as an Adjunct After Scaling and Root Planing - A Prospective Randomized Clinical Trial. Journal of periodontology, 84(7), pp. 941-949. Chicago, Ill.: American Academy of Periodontology 10.1902/jop.2012.120269

[img] Text
jop%2E2012%2E120269.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

Aim: The study was designed to determine the effect on clinical variables, subgingival bacteria and local immune response brought about by additional application of hyaluronan-containing gels in early wound healing after scaling and root planing (SRP). Material and Methods: In this randomised clinical study, data from 34 individuals with chronic periodontitis was evaluated after full-mouth SRP. In the test group (n = 17), hyaluronan gels in two molecular weights were additionally applied during the first two weeks after SRP. The control group (n = 17) was treated with SRP only. Probing depth (PD) and attachment level (AL) were recorded at baseline and after 3 and 6 months, and subgingival plaque and sulcus fluid samples were taken for microbiological and biochemical analysis. Results: In both groups, PD and AL were significantly reduced (p < 0.001). The changes in PD and the reduction of the numbers of pockets with PD ≥ 5mm were significantly higher in the test group after 3 (p = 0.014; p = 0.021) and 6 months (p = 0.046; p = 0.045). Six months after SRP, the counts of Treponema denticola were significantly reduced in both groups (both p = 0.043), those of Campylobacter rectus in the test group only (p = 0.028). Prevotella intermedia and Porphyromonas gingivalis increased in the control group. Conclusions: The adjunctive application of hyaluronan may have positive effects on probing depth reduction and may prevent recolonization by periodontopathogens.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Eick, Sigrun, Jentsch, Holger


600 Technology > 610 Medicine & health




American Academy of Periodontology




Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:30

Last Modified:

05 Dec 2022 14:09

Publisher DOI:


PubMed ID:





https://boris.unibe.ch/id/eprint/11245 (FactScience: 217315)

Actions (login required)

Edit item Edit item
Provide Feedback