Healthy lifestyle and glucagon-like peptide-1 in young and healthy adults: A population-based study.

Krisai, Philipp; Aeschbacher, Stefanie; Ruperti Repilado, Francisco Javier; Schoen, Tobias; Reusser, Andreas; Meier, Manuel; Todd, John; Estis, Joel; Risch, Martin; Risch, Lorenz; Conen, David (2017). Healthy lifestyle and glucagon-like peptide-1 in young and healthy adults: A population-based study. Preventive medicine, 101, pp. 72-76. Elsevier 10.1016/j.ypmed.2017.05.025

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A healthy lifestyle is associated with a lower risk of cardiovascular events and mortality, but underlying mechanisms are not fully understood. The aim of our study was to investigate the relationships between a healthy lifestyle and glucagon-like peptide-1 (GLP-1), an incretin hormone with both glycemic and cardiovascular properties. Healthy participants aged 25-41years without cardiovascular disease, diabetes or a body mass index (BMI) >35kg/mwere enrolled in a population-based study. The following metrics were used to build a lifestyle score ranging from 0 to 7 (a higher score indicating a healthier lifestyle): blood pressure (BP) (<120/80mmHg), plasma levels of glycated hemoglobin (<5.7%), total cholesterol levels (<200mg/dl), BMI (<25kg/m), not smoking cigarettes, moderate (≥150min/week) or vigorous (≥75min/week) physical activity and a healthy diet. Among 2133 participants median age was 36.7years and 53.3% were female. GLP-1 levels decreased significantly from 39.5 to 30.9ng/l (p<0.0001) across increasing lifestyle score categories. This linear relationship persisted in multivariable adjusted linear regression models (B for GLP-1 per 1-unit increase of the lifestyle score -0.06; 95% confidence intervals -0.07, -0.04; p<0.0001). Individual health metrics that were significantly associated with GLP-1 were a normal BMI (-0.07; -0.12, -0.03; p=0.001), low total cholesterol levels (-0.07; -0.12, -0.03; p=0.001), normal BP (-0.05; -0.10, -0.00; p=0.047) and not smoking (-0.06; -0.10, -0.01; p=0.01). A healthy lifestyle is strongly associated with lower GLP-1 levels in young and healthy adults.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Risch, Lorenz

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0091-7435

Publisher:

Elsevier

Language:

English

Submitter:

Marie-Christine Müller

Date Deposited:

29 Mar 2018 10:50

Last Modified:

23 Oct 2019 12:18

Publisher DOI:

10.1016/j.ypmed.2017.05.025

PubMed ID:

28579495

Uncontrolled Keywords:

Diabetes mellitus Epidemiology Glucagon-like peptide-1 Hypertension Insulin resistance Lifestyle

BORIS DOI:

10.7892/boris.112498

URI:

https://boris.unibe.ch/id/eprint/112498

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