Subclinical sleep apnoea and plasma levels of endothelin-1 among young and healthy adults.

Schoen, Tobias; Aeschbacher, Stefanie; Leuppi, Joerg D; Miedinger, David; Werthmüller, Ursina; Estis, Joel; Todd, John; Risch, Martin; Risch, Lorenz; Conen, David (2017). Subclinical sleep apnoea and plasma levels of endothelin-1 among young and healthy adults. Open Heart, 4(1), e000523. B M J Group 10.1136/openhrt-2016-000523

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OBJECTIVE Obstructive sleep apnoea (OSA) is a risk factor for vascular disease and other adverse outcomes. These associations may be at least partly due to early endothelin-1 (ET-1)-mediated endothelial dysfunction (ED). Therefore, we assessed the relationships between subclinical sleep apnoea and plasma levels of ET-1. METHODS We performed a population-based study among 1255 young and healthy adults aged 25-41 years. Cardiovascular disease, diabetes or a body mass index >35 kg/mwere exclusion criteria. Plasma levels of ET-1 were measured using a high-sensitivity, single-molecule counting technology. The relationships between subclinical sleep apnoea (OSA indices: respiratory event index (REI), oxygen desaturation index (ODI), mean night-time blood oxygen saturation (SpO)) and ET-1 levels were assessed by multivariable linear regression analysis. RESULTS Median age of the cohort was 35 years. Median ET-1 levels were 2.9 (IQR 2.4-3.6) and 2.5 pg/mL (IQR 2.1-3.0) among patients with (n=105; 8%) and without subclinical sleep apnoea (REI 5-14), respectively. After multivariable adjustment, subclinical sleep apnoea remained significantly associated with plasma levels of ET-1 (β=0.13 (95% CI 0.06 to 0.20) p=0.0002 for a REI 5-14; β=0.10 (95% CI 0.03 to 0.16) p=0.003 for an ODI≥5). Every 1% decrease in mean night-time SpOincreased ET-1 levels by 0.1 pg/mL, an association that remained significant after multivariable adjustment (β=0.02 (95% CI 0.003 to 0.033) p=0.02). CONCLUSIONS In this study of young and healthy adults, we found that participants with subclinical sleep apnoea had elevated plasma ET-1 levels, an association that was due to night-time hypoxaemia. Our results suggest that ED may already be an important consequence of subclinical sleep apnoea.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Risch, Lorenz

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2053-3624

Publisher:

B M J Group

Language:

English

Submitter:

Marie-Christine Müller

Date Deposited:

28 Mar 2018 13:34

Last Modified:

23 Oct 2019 06:16

Publisher DOI:

10.1136/openhrt-2016-000523

PubMed ID:

28409007

Uncontrolled Keywords:

ENDOTHELIN-1 HYPOXEMIA SLEEP APNEA

BORIS DOI:

10.7892/boris.112499

URI:

https://boris.unibe.ch/id/eprint/112499

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