Healthy Lifestyle and Blood Pressure Variability in Young Adults.

Maseli, Anna; Aeschbacher, Stefanie; Schoen, Tobias; Fischer, Andreas; Jung, Manuel; Risch, Martin; Risch, Lorenz; Conen, David (2017). Healthy Lifestyle and Blood Pressure Variability in Young Adults. American journal of hypertension, 30(7), pp. 690-699. Oxford University Press 10.1093/ajh/hpx034

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BACKGROUND The aim of this study was to assess the relationships between healthy lifestyle metrics and blood pressure variability (BPV) in young and healthy adults. METHODS A population-based sample of 1,999 individuals aged 25-41 years was investigated. A lifestyle-score from 0 (most unhealthy) to 7 (most healthy) was calculated by giving one point for each of the following components: never smoking cigarettes, adhering to a healthy diet, performing moderate or intense physical activity, having a body mass index <25 kg/m2, a total cholesterol <200 mg/dl, a glycated hemoglobin <5.7%, or a conventional BP <120/80 mm Hg. Standardized ambulatory 24-hour BP measurements were obtained in all individuals. BPV was defined as the SD of all individual ambulatory BP recordings. We constructed multivariable linear regression models to assess the relationships between the lifestyle-score and BPV. None of the results were adjusted for multiple testing. RESULTS Median age was 37 years and 46.8% were men. With increasing lifestyle-score, systolic and diastolic BPV is decreasing linearly (P for trend <0.0001), even after multivariable adjustment. Per 1-point increase in lifestyle-score, the β-coefficient (95% confidence interval) for systolic and diastolic 24-hour BPV was -0.03 (-0.03; -0.02) and -0.04 (-0.05; -0.03), respectively, both P for trend <0.0001. These relationships were attenuated but remained statistically significant after additional adjustment for mean individual BP. CONCLUSION In this study of young and healthy adults, adopting a healthy lifestyle was associated with a lower BPV. These associations were independent of mean BP levels.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Risch, Lorenz

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0895-7061

Publisher:

Oxford University Press

Language:

English

Submitter:

Marie-Christine Müller

Date Deposited:

27 Mar 2018 10:15

Last Modified:

27 Mar 2018 10:15

Publisher DOI:

10.1093/ajh/hpx034

PubMed ID:

28402434

Uncontrolled Keywords:

blood pressure blood pressure variability healthy lifestyle hypertension lifestyle-score population-based.

URI:

https://boris.unibe.ch/id/eprint/112500

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