Effects of 0.005% latanoprost solution on intraocular pressure in healthy dogs and cats.

Studer, M. E.; Martin, C L; Stiles, J (2000). Effects of 0.005% latanoprost solution on intraocular pressure in healthy dogs and cats. American journal of veterinary research, 61(10), pp. 1220-1224. American Veterinary Medical Association 10.2460/ajvr.2000.61.1220

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OBJECTIVE To evaluate effects of daily topical ocular administration of latanoprost solution on intraocular pressure (IOP) in healthy cats and dogs. ANIMALS 9 domestic shorthair cats and 14 dogs. PROCEDURE Latanoprost solution (0.005%) was administered topically to 1 eye (treated) and vehicle to the other eye (control) of all animals once daily in the morning for 8 days. Intraocular pressure was measured twice daily for the 5 days preceding treatment, and IOP, pupillary diameter, conjunctival hyperemia, and blepharospasm were measured 0, 1, 6, and 12 hours after the first 4 treatments and 0 and 12 hours after the final 4 treatments. Measurements continued twice a day for 5 days after treatment was discontinued. Aqueous flare was measured once daily during and for 5 days after the treatment period. RESULTS Intraocular pressure and pupillary diameter were significantly decreased in the treated eye of dogs, compared with the control eye. Mild conjunctival hyperemia was also detected, but severity did not differ significantly between eyes. Blepharospasm and aqueous flare were not detected in either eye. Intraocular pressure in cats was not significantly affected by treatment with latanoprost. However, pupillary diameter was significantly decreased in the treated eye, compared with the control eye. Conjunctival hyperemia, aqueous flare, and blepharospasm were not detected in either eye. CONCLUSIONS AND CLINICAL RELEVANCE Once-daily topical ocular administration of latanoprost solution (0.005%) reduced IOP in healthy dogs without inducing adverse effects but did not affect IOP in healthy cats. Latanoprost may be useful for treating glaucoma in dogs.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic

UniBE Contributor:

Stengard, Michele

Subjects:

600 Technology > 630 Agriculture

ISSN:

0002-9645

Publisher:

American Veterinary Medical Association

Language:

English

Submitter:

Michele Stengard

Date Deposited:

20 Jun 2018 09:05

Last Modified:

24 Oct 2019 05:45

Publisher DOI:

10.2460/ajvr.2000.61.1220

PubMed ID:

11039551

BORIS DOI:

10.7892/boris.112509

URI:

https://boris.unibe.ch/id/eprint/112509

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