The effects of intravenous romifidine on intraocular pressure in clinically normal horses and horses with incidental ophthalmic findings.

Stine, Jessica M; Michau, Tammy M; Williams, Megan K; Kuebelbeck, Karen Leann; Stengard, Michele E. (2014). The effects of intravenous romifidine on intraocular pressure in clinically normal horses and horses with incidental ophthalmic findings. Veterinary ophthalmology, 17(Suppl 1), pp. 134-139. Blackwell Science 10.1111/vop.12172

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DESIGN Original study. OBJECTIVE To evaluate the effect of sedation with romifidine hydrochloride 1% (Sedivet: Boehringer-Ingelheim) on intraocular pressure (IOP) in the normal horse and horses with incidental ophthalmic findings as measured by applanation tonometry. ANIMALS Nineteen clinically normal horses (13 geldings, six mares) and eight horses (three geldings, five mares) with incidental ophthalmic findings were included in this study. PROCEDURES All horses underwent complete ophthalmic examination with pharmacologic mydriasis a minimum of 2 weeks prior to IOP evaluation. Baseline intraocular pressure values were obtained following auriculopalpebral nerve block and topical anesthetic. Immediately thereafter, romifidine was administered intravenously (75 µg/kg) and the IOP recorded at 5, 15, 30, 45 and 60 min postsedation in both eyes. Five successive readings were obtained at each time point, the low and high value discarded, and three remaining readings averaged for a mean. RESULTS The changes with time were consistent between eyes and OD and OS results were pooled. The mean IOP at baseline was 26.35 ± 5.57 mmHg. Mean IOP values were significantly lower than baseline at 5 (P < 0.0001), 15 (P < 0.0001), 30 (P = 0.0003), 45 (P < 0.0001) and 60 (P = 0.0005) minutes. The largest change from baseline (16.7%) was noted at t = 15 min. CONCLUSIONS AND CLINICAL RELEVANCE Administration of romifidine significantly decreased the IOP from baseline at all time points measured. The greatest decline in IOP was noted at 15 min postsedation. Results are consistent with other studies noting a decline in IOP with administration of α-2 agonists.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic

UniBE Contributor:

Stengard, Michele

Subjects:

600 Technology > 630 Agriculture

ISSN:

1463-5216

Publisher:

Blackwell Science

Language:

English

Submitter:

Michele Stengard

Date Deposited:

06 Jul 2018 11:13

Last Modified:

06 Jul 2018 11:13

Publisher DOI:

10.1111/vop.12172

PubMed ID:

24787635

Uncontrolled Keywords:

alpha-2 agonist equine intraocular pressure romifidine sedation tonometry

URI:

https://boris.unibe.ch/id/eprint/112511

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