Transition Metal-based Anticancer Drugs Targeting Nucleic Acids: A Tandem Mass Spectrometric Investigation

Eberle, RahelP.; Hari, Yvonne Ilona; Schürch, Stefan (2017). Transition Metal-based Anticancer Drugs Targeting Nucleic Acids: A Tandem Mass Spectrometric Investigation. CHIMIA, 71(3), pp. 120-123. Schweizerische Chemische Gesellschaft 10.2533/chimia.2017.120

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The search for effective drugs against cisplatin-resistant tumors resulted in a large number of organometallic compounds that are evaluated for their antiproliferative activity. Among the most promising candidates are bent metallocenes based on various transition metal ions and ligands. The elucidation of structural features and the characterization of the interaction of a drug candidate with its target require accurate and sensitive analytical tools. Tandem mass spectrometry is applied to the investigation of the adduct sites and binding patterns of metallodrugs bound to single-stranded oligonucleotides and higher-order nucleic acids. Results reveal the binding specificities of the different metallodrugs and demonstrate the influence they exert on the dissociation pathways of the adducts in the gas-phase.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Hari, Yvonne Ilona and Schürch, Stefan

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
500 Science
600 Technology > 610 Medicine & health

ISSN:

0009-4293

Publisher:

Schweizerische Chemische Gesellschaft

Language:

English

Submitter:

Stefan Schürch

Date Deposited:

16 Apr 2018 12:41

Last Modified:

16 Apr 2018 12:41

Publisher DOI:

10.2533/chimia.2017.120

PubMed ID:

28351457

URI:

https://boris.unibe.ch/id/eprint/112529

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