Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography.

Yamamoto, Erika; Xing, Lei; Higuma, Takumi; Minami, Yoshiyasu; Bryniarski, Krzysztof; Zanchin, Thomas; Wang, Zhao; Aguirre, Aaron D; Lee, Hang; Jang, Ik-Kyung (2017). Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography. Coronary artery disease, 28(7), pp. 557-563. Lippincott Williams & Wilkins 10.1097/MCA.0000000000000534

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OBJECTIVES Certain neointimal patterns including neoatherosclerosis (NA) are known to be associated with poor clinical outcome. The prevalence and time course of different neointimal patterns have not been studied systematically. The aim of this study was to investigate the serial changes in neointimal pattern after drug-eluting stent implantation. PATIENTS AND METHODS A total of 132 patients with 207 drug-eluting stents, who underwent two follow-up optical coherence tomography studies at 6 and 12 months, were included. Neointimal patterns were categorized as homogeneous, heterogeneous, layered, or NA using optical coherence tomography. Quantitative and qualitative analyses of neointima were carried out. RESULTS Both at 6 and at 12 months, the homogenous neointima was the predominant type (>75%), followed by the layered and the heterogeneous pattern. At 12 months, progression to NA was observed in 0.6% of the patients in the homogeneous group, in 5.6% of the patients in the heterogeneous group, and in 3.9% of the patients in the layered group. Regression to the homogeneous pattern was observed in 5.6% of the patients in the heterogeneous group and 11.5% of the patients in the layered group. CONCLUSION The homogenous neointima is the predominant pattern both at 6 and at 12 months. The neointimal pattern changed between 6 and 12 months in 10.6% of stents. Further studies are needed to understand the mechanisms of these neointimal changes and their clinical significance.

Item Type:

Journal Article (Original Article)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

ISSN:

0954-6928

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Marlene Wolf Tobler

Date Deposited:

16 May 2018 08:12

Last Modified:

22 Oct 2019 22:06

Publisher DOI:

10.1097/MCA.0000000000000534

PubMed ID:

28704243

BORIS DOI:

10.7892/boris.112540

URI:

https://boris.unibe.ch/id/eprint/112540

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