Diffusion imaging studies of Huntington's disease: A meta-analysis.

Liu, Wanglin; Yang, Jing; Burgunder, Jean-Marc; Cheng, Bochao; Shang, Huifang (2016). Diffusion imaging studies of Huntington's disease: A meta-analysis. Parkinsonism & related disorders, 32, pp. 94-101. Elsevier 10.1016/j.parkreldis.2016.09.005

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BACKGROUND Diffusion tensor imaging (DTI) could detect abnormal brain microstructural alterations. DTI studies of Huntington's Disease(HD) have yielded inconsistent results. OBJECTIVE To integrate the existing DTI studies of HD and explore the validity of DTI to detect microstructural damages in HD brain via meta-analysis. METHODS Systematic and comprehensive searches of the databases were performed for DTI studies of HD. The data from the studies that met our inclusion criteria were extracted and analyzed using the CMA2 software. Random effect models were utilized to minimize the potential between-study heterogeneity. One-way sensitivity analysis was conducted to test the robustness of the results. RESULTS The meta-analysis included 140 pre-symptomatic HD (PreHD), 235 symptomatic HD (SymHD) patients and 302 controls, revealing significantly increased fractional anisotropy (FA) in the caudate, putamen, and globus pallidus, while decreased FA in the corpus callosum of both PreHD and SymHD patients compared with controls. In addition, significantly increased mean diffusivity (MD) was identified in the putamen and thalamus of both PreHD and SymHD patients, and in the caudate of SymHD patients, while no significant difference in MD in the caudate of PreHD patients. In the corpus callosum, there was a significant increase of radial diffusivity and axial diffusivity in SymHD patients compared with controls. Meta-regression showed gender-based difference in MD values of the caudate. CONCLUSIONS Our meta-analysis provides further evidence that DTI detects microstructural damage of both white matter and gray matter even in PreHD gene carriers. MD is less sensitive than FA in detecting structural changes in PreHD.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Burgunder, Jean-Marc


600 Technology > 610 Medicine & health








Stefanie Hetzenecker

Date Deposited:

05 Jun 2018 09:45

Last Modified:

23 Oct 2019 19:48

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Diffusion tensor imaging (DTI) Fractional anisotropy (FA) Huntington's disease Mean diffusivity (MD) Microstructural





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