Management of cervical premalignant lesions.

Basu, Partha; Taghavi, Katayoun; Hu, Shang-Ying; Mogri, Sushma; Joshi, Smita (2018). Management of cervical premalignant lesions. Current Problems in Cancer, 42(2), pp. 129-136. Elsevier: 12 months 10.1016/j.currproblcancer.2018.01.010

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Treatment of cervical premalignant lesions (cervical intraepithelial neoplasia; CIN) of different grades is very effective, simple, and safe. The entire transformation zone of the cervix needs to be treated either by an ablative technique (cryotherapy or thermal ablation) or an excisional technique (large loop excision of transformation zone or cold knife conization); the choice of treatment depends on the size and location of the lesion and the type of the transformation zone. The cure rate after ablative treatment of high-grade CIN may be little lower than that after excisional treatment. The simplicity of the technique, low complication rate, and lesser cost make ablative technique the treatment of choice in the low resourced settings for the eligible lesions. In situations where organizing colposcopy and histopathology services is challenging, simple algorithms like screening with visual inspection with acetic acid test and immediate ablative treatment of the visual inspection with acetic acid-positive women has been recommended by the World Health Organization. Such a strategy is effective in preventing subsequent development of high-grade CIN and also ensures high compliance of the screen positive women to treatment.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Taghavi, Katayoun


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services




Elsevier: 12 months




Tanya Karrer

Date Deposited:

09 Mar 2018 14:58

Last Modified:

26 Oct 2019 14:23

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cervical cancer screening Cervical intraepithelial neoplasia Cryotherapy Large loop excision of transformation zone Management Thermal ablation




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