Sodium intake and multiple sclerosis activity and progression in BENEFIT.

Fitzgerald, Kathryn C; Munger, Kassandra L; Hartung, Hans-Peter; Freedman, Mark S; Montalbán, Xavier; Edan, Gilles; Wicklein, Eva-Maria; Radue, Ernst-Wilhelm; Kappos, Ludwig; Pohl, Christoph; Ascherio, Alberto; BENEFIT, Study Group (2017). Sodium intake and multiple sclerosis activity and progression in BENEFIT. Annals of neurology, 82(1), pp. 20-29. Wiley-Blackwell 10.1002/ana.24965

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OBJECTIVE To assess whether a high-salt diet, as measured by urinary sodium concentration, is associated with faster conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) and MS activity and disability. METHODS BENEFIT was a randomized clinical trial comparing early versus delayed interferon beta-1b treatment in 465 patients with a CIS. Each patient provided a median of 14 (interquartile range = 13-16) spot urine samples throughout the 5-year follow-up. We estimated 24-hour urine sodium excretion level at each time point using the Tanaka equations, and assessed whether sodium levels estimated from the cumulative average of the repeated measures were associated with clinical (conversion to MS, Expanded Disability Status Scale [EDSS]) and magnetic resonance imaging (MRI) outcomes. RESULTS Average 24-hour urine sodium levels were not associated with conversion to clinically definite MS over the 5-year follow-up (hazard ratio [HR] = 0.91, 95% confidence interval [CI] = 0.67-1.24 per 1g increase in estimated daily sodium intake), nor were they associated with clinical or MRI outcomes (new active lesions after 6 months: HR = 1.05, 95% CI = 0.97-1.13; relative change in T2 lesion volume: -0.11, 95% CI = -0.25 to 0.04; change in EDSS: -0.01, 95% CI = -0.09 to 0.08; relapse rate: HR = 0.78, 95% CI = 0.56-1.07). Results were similar in categorical analyses using quintiles. INTERPRETATION Our results, based on multiple assessments of urine sodium excretion over 5 years and standardized clinical and MRI follow-up, suggest that salt intake does not influence MS disease course or activity. Ann Neurol 2017;82:20-29.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology


600 Technology > 610 Medicine & health








Stefanie Hetzenecker

Date Deposited:

27 Mar 2018 11:14

Last Modified:

03 Nov 2019 22:16

Publisher DOI:


PubMed ID:


Additional Information:

Heinrich Mattle (Neurologie) ist Teil der Benefit Study Group.




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