Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities.

Harmse, Rozanne; Wong, Ho Ning; Smit, Frans J; Müller, Joachim; Hemphill, Andrew; N'Da, David D; Haynes, Richard K (2017). Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities. ChemMedChem, 12(24), pp. 2094-2098. Wiley-VCH 10.1002/cmdc.201700600

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Neosporosis caused by the apicomplexan parasite Neospora caninum is an economically important disease that induces abortion in dairy and beef cattle. There are no vaccines or drugs available on the market for control or treatment of the disease in bovines. The peroxide artemisinin and its derivatives used clinically for treatment of malaria are active against N. caninum and other apicomplexan parasites. We have now evaluated the activities of the readily accessible and chemically robust 11-azaartemisinin 5 and selected N-sulfonyl derivatives prepared as described in the accompanying paper against N. caninum tachyzoites grown in infected human foreskin fibroblasts. Azaartemisinin elicited an ICvalue of 150 nm, and the 2',5'-dichloro-3'-thienylsulfonyl-11-azaartemisinin 17 was found to be the most active, with an ICvalue of 40 nm. Comparison with normal human fetal lung fibroblasts HFLF WI-38 revealed relatively benign cytotoxicity. The compounds were also screened in vitro against TK-10 (renal), UACC-62 (melanoma) and MCF-7 (breast) cancer cell lines; overall, in line with activities against HFLF cells, most compounds in the series were found to be inactive.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Müller, Joachim and Hemphill, Andrew

Subjects:

600 Technology > 630 Agriculture
500 Science
500 Science > 540 Chemistry
500 Science > 570 Life sciences; biology

ISSN:

1860-7179

Publisher:

Wiley-VCH

Language:

English

Submitter:

Andrew Hemphill

Date Deposited:

17 May 2018 16:43

Last Modified:

22 Oct 2019 18:43

Publisher DOI:

10.1002/cmdc.201700600

PubMed ID:

29210523

Uncontrolled Keywords:

Neospora caninum antitumor apicomplexan artemisinin azaartemisinin

BORIS DOI:

10.7892/boris.113106

URI:

https://boris.unibe.ch/id/eprint/113106

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