Neosporosis in animals

Dubey, Jitender; Hemphill, Andrew; Calero-Bernal, Rafael; Schares, Gereon (2017). Neosporosis in animals [Textbook] . Boca Raton, FL: CRC Press

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In the 1980’s a neuromuscular syndrome of dogs simulating toxoplasmosis was recognized. In 1988, a new genus, Neospora, and the type species, Neospora caninum, were named, cultivated in vitro, and differentiated from Toxoplasma gondii. A year later, N. caninum was identified as an etiological agent for bovine abortions. Considerable progress in understanding the biology of neosporosis has been made in the last 30 years, resulting in more than 2000 scientific publications. The economic importance of abortion in cattle, and the availability of knowledge, reagents, and technology used to study toxoplasmosis, have contributed to the rapid progress in understanding the biology of neosporosis. Whole genome sequencing of N. caninum confirmed close similarities between N. caninum and T. gondii. However, these 2 protozoans are biologically different: N. caninum causes a major disease in cattle, and canids are its definitive hosts, whereas toxoplasmosis is a major public health problem and felids are its definitive host. Both parasites have wide host range. Here we summarize information on the biology of neosporosis, starting with a chapter 1 on the historical background. Subsequent chapters deal with general aspects of the biology of N. caninum (chapter 2), techniques (chapter 3), and the disease caused by this parasite in cattle (chapter 4), dogs (chapter 5), and all other animals including primates and humans (chapters 6-18). Abortion is a worldwide problem in livestock industry accounting for annual economical losses of billions of dollars, and N. caninum is a major cause of it. Neosporosis causes abortion in both dairy and beef cattle. Abortions not only occur in cattle that have been exposed recently but also in chronically infected cattle, which poses a major challenge for vaccine development. There is no effective vaccine or therapy to eliminate N. caninum in cattle, but progress is being made. In this book, we provide an up to date account of structure, biology, clinical disease, diagnosis, epidemiology, treatment, attempts at immunoprophylaxis, and control in all hosts. There are 175 illustrations on the life cycle, structure of parasitic stages, and of lesions. More than 2100 references are cited. It is hoped that this book will be useful to biologists, veterinarians, and researchers.

Item Type:

Book (Textbook)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Hemphill, Andrew

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISBN:

978-1-4987-5254-1

Publisher:

CRC Press

Language:

English

Submitter:

Andrew Hemphill

Date Deposited:

23 May 2018 09:26

Last Modified:

16 Aug 2018 15:49

URI:

https://boris.unibe.ch/id/eprint/113114

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