Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging.

Schawkat, Khoschy; Ith, Michael; Christe, Andreas; Kühn, Wolfgang; Chittazhathu Kurian Kuruvilla, Yojena; Bains, Lauren; Runge, Val Murray; Heverhagen, Johannes (2018). Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging. European radiology, 28(6), pp. 2389-2396. Springer 10.1007/s00330-017-5227-8

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OBJECTIVES To investigate prospectively the repeatability of pancreatic perfusion measurements using arterial spin labelling (ASL) and to determine the increase in perfusion due to secretin stimulation. MATERIAL AND METHODS An (FAIR)-TrueFISP ASL sequence was applied to determine the perfusion of the pancreatic head in a 3T MRI scanner. Ten healthy volunteers (four men, six women: mean age 28.5 ± 4.6 years; age range 25-40 years) were investigated twice within 1 week. The inter-individual variability was calculated using the standard deviation. Intra-individual agreement between the first and second scan was estimated using the Pearson correlation coefficient. A paired Wilcoxon rank-sum test was used to compare perfusion at baseline (BL) and during secretin stimulation. RESULTS The mean BL perfusion of the pancreatic head was 285 ± 96 mL/100 g/min with an intra-individual correlation coefficient of 0.67 (strong) for repeated measurements. Secretin stimulation led to a significant increase (by 81%) in perfusion of the pancreatic head to 486 ±156 mL/100 g/min (p=0.002) with an intra-individual correlation of 0.29 (weak). A return to BL values was observed after 239 ± 92 s with a moderate intra-individual correlation coefficient of 0.42 for repeat measurements. CONCLUSION Dynamic non-invasive ASL imaging of the pancreas permitted quantification of pancreatic perfusion in a clinically applicable setting. KEY POINTS • ASL imaging of the pancreas permitted quantification of pancreatic perfusion • Secretin stimulation led to a significant increase in pancreatic perfusion • The intra-individual correlation coefficient for baseline perfusion was strong for repeated measurements.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radiologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radiologie

UniBE Contributor:

Schawkat, Khoschy; Ith, Michael; Christe, Andreas; Kühn, Wolfgang; Runge, Val Murray and Heverhagen, Johannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0938-7994

Publisher:

Springer

Language:

English

Submitter:

Nicole Rösch

Date Deposited:

23 Apr 2018 08:48

Last Modified:

05 Nov 2019 08:19

Publisher DOI:

10.1007/s00330-017-5227-8

PubMed ID:

29302785

Uncontrolled Keywords:

Arterial spin labelling MRI Pancreas Perfusion Secretin

BORIS DOI:

10.7892/boris.113284

URI:

https://boris.unibe.ch/id/eprint/113284

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