Coordinated neural, behavioral, and phenomenological changes in perceptual plasticity through overtraining of synesthetic associations

Rothen, Nicolas; Schwartzman, David J.; Bor, Daniel; Seth, Anil K. (2018). Coordinated neural, behavioral, and phenomenological changes in perceptual plasticity through overtraining of synesthetic associations. Neuropsychologia, 111, pp. 151-162. Elsevier 10.1016/j.neuropsychologia.2018.01.030

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Synesthesia is associated with additional perceptual experiences, which are automatically and consistently triggered by specific inducing stimuli. Synesthesia is also accompanied by more general sensory and cortical changes, including enhanced modality-specific cortical excitability. Extensive cognitive training has been shown to generate synesthesia-like phenomenology but whether these experiences are accompanied by neurophysiological changes characteristic of synesthesia remains unknown. Addressing this question provides a unique opportunity to elucidate the neural basis of perceptual plasticity relevant to conscious experiences. Here we investigate whether extensive training of letter-color associations leads not only to synesthetic experiences, but also to changes in cortical excitability. We confirm that overtraining synesthetic associations results in synesthetic phenomenology. Stroop tasks further reveal synesthesia-like performance following training. Electroencephalography and transcranial magnetic stimulation show, respectively, enhanced visual evoked potentials (in response to untrained patterns) and lower phosphene thresholds, demonstrating specific cortical changes. An active (using letter-symbol training) and a passive control confirmed these results were due to letter-color training and not simply to repeated testing. Summarizing, we demonstrate specific cortical changes, following training-induced acquisition of synesthetic phenomenology that are characteristic of genuine synesthesia. Collectively, our data reveal dramatic plasticity in human visual perception, expressed through a coordinated set of behavioral, neurophysiological, and phenomenological changes.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Psychological and Behavioral Health

UniBE Contributor:

Rothen, Nicolas

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

0028-3932

Publisher:

Elsevier

Language:

English

Submitter:

Nicolas Rothen

Date Deposited:

09 May 2018 08:25

Last Modified:

29 Oct 2019 03:44

Publisher DOI:

10.1016/j.neuropsychologia.2018.01.030

PubMed ID:

29378205

BORIS DOI:

10.7892/boris.113340

URI:

https://boris.unibe.ch/id/eprint/113340

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