Characterization of therapeutic oligonucleotides

Schürch, Stefan (19 October 2017). Characterization of therapeutic oligonucleotides (Unpublished). In: Thermo Fisher Scientific, 2017 LCMS User Meeting. Basel, Switzerland. 19, October 2017.

Nucleic acids are involved in the storage and processing of genetic information and contribute to the regulation of various cellular processes. Thus, they represent attractive targets for drugs against gene-related diseases. On the other hand, structurally modified antisense oligonucleotides are designed to specifically interfere with gene expression at the mRNA level. This presentation gives an overview of our recent research activities focused on the tandem mass spectrometric characterization of therapeutic oligonucleotides and the interaction of transition metal-based anti-cancer drugs with their nucleic acid targets.

Item Type:

Conference or Workshop Item (Speech)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Schürch, Stefan

Subjects:

500 Science > 540 Chemistry
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

Language:

English

Submitter:

Stefan Schürch

Date Deposited:

13 Apr 2018 15:31

Last Modified:

13 Apr 2018 15:31

URI:

https://boris.unibe.ch/id/eprint/113521

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